A mechanistic model for genetic machinery of ontogenetic growth

Genetics
Rongling WuJames M Cheverud

Abstract

Two different genetic mechanisms can be proposed to explain variation in growth trajectories. The allelic sensitivity hypothesis states that growth trajectory is controlled by the time-dependent expression of alleles at the deterministic quantitative trait loci (dQTL) formed during embryogenesis. The gene regulation hypothesis states that the differentiation in growth process is due to the opportunistic quantitative trait loci (oQTL) through their mediation with new developmental signals. These two hypotheses of genetic control have been elucidated in the literature. Here, we propose a new statistical model for discerning these two mechanisms in the context of growth trajectories by integrating growth laws within a QTL-mapping framework. This model is developed within the maximum-likelihood context, implemented with a grid approach for estimating the genomic positions of the deterministic and opportunistic QTL and the simplex algorithm for estimating the growth curve parameters of the genotypes at these QTL and the parameters modeling the residual (co)variance matrix. Our model allows for extensive hypothesis tests for the genetic control of growth processes and developmental events by these two types of QTL. The application of...Continue Reading

References

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Citations

Aug 18, 2009·Journal of Mathematical Biology·Jiangtao LuoRongling Wu
Mar 4, 2010·Genetics Research·Tianbo JinRongling Wu
Dec 6, 2011·Briefings in Bioinformatics·Xiyang ZhaoRongling Wu
Mar 30, 2007·Bioinformatics·Min LinRongling Wu
Nov 26, 2009·Biological Reviews of the Cambridge Philosophical Society·Yao Li, Rongling Wu
Apr 18, 2008·Theoretical Biology & Medical Modelling·Kiranmoy Das, Rongling Wu
Aug 30, 2012·Briefings in Bioinformatics·Zhong WangRongling Wu
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tomas HrbekJames M Cheverud
Apr 2, 2013·Briefings in Bioinformatics·Zhongwen HuangRongling Wu
Jul 28, 2009·Journal of Theoretical Biology·Ning LiRongling Wu
Apr 12, 2016·BioMed Research International·Jiandong QiJianxin Wang
May 3, 2006·Journal of Theoretical Biology·Hongying LiRongling Wu
Dec 12, 2018·The Plant Journal : for Cell and Molecular Biology·Mengmeng SangRongling Wu
Feb 9, 2006·Physiological Genomics·Yuehua CuiRongling Wu

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