A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging

Journal of Controlled Release : Official Journal of the Controlled Release Society
Erik KaunistoAnders Axelsson

Abstract

In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.

References

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Citations

Jan 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ali SalehiRonald G Larson
Jan 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryan S TellerPatrick F Kiser
Jan 10, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Erik KaunistoAnders Axelsson
Jan 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KrenzlinF Siepmann
Jul 12, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Igor V Koptyug
Nov 19, 2011·Drug Discovery Today·Przemysław P DorożyńskiGreg J Stanisz
Feb 15, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anna ViridénAnette Larsson
Jan 25, 2011·International Journal of Pharmaceutics·Erik KaunistoAnders Axelsson
Apr 2, 2015·International Journal of Pharmaceutics·Diego CaccavoAnna Angela Barba
Mar 6, 2012·International Journal of Pharmaceutics·Jari PajanderJesper Ostergaard
Dec 12, 2012·Carbohydrate Polymers·Gaetano LambertiAnna Angela Barba
Nov 5, 2016·International Journal of Pharmaceutics·A F R PimentaB Saramago
Jun 22, 2017·International Journal of Pharmaceutics·Diego CaccavoAnette Larsson
Dec 7, 2019·International Journal of Pharmaceutics·Shivprasad DeshmukhAdrian Kelly
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Urša Mikac, Julijana Kristl
Aug 27, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Youcef BenzineYouness Karrout

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