A mechanistic review on plant-derived natural compounds as dietary supplements for prevention of inflammatory bowel disease

Expert Review of Gastroenterology & Hepatology
Mohammad H FarzaeiNima Rezaei

Abstract

Inflammatory bowel disease (IBD) is a recurrent idiopathic inflammatory condition, characterized by disruption of the gut mucosal barrier. This mechanistic review aims to highlight the significance of plant-derived natural compounds as dietary supplements, which can be used in addition to restricted conventional options for the prevention of IBD and induction of remission. Various clinical trials confirmed the effectiveness and tolerability of natural supplements in patients with IBD. Mounting evidence suggests that these natural compounds perform their protective and therapeutic effect on IBD through numerous molecular mechanisms, including anti-inflammatory and immunoregulatory, anti-oxidative stress, modulation of intracellular signaling transduction pathways, as well as improving gut microbiota. In conclusion, natural products can be considered as dietary supplements with therapeutic potential for IBD, provided that their safety and efficacy is confirmed in future well-designed clinical trials with adequate sample size.

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Citations

Sep 7, 2018·Journal of Cellular Physiology·Mohammad Hosein FarzaeiSeyed Mohammad Nabavi
Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
May 4, 2017·World Journal of Gastroenterology : WJG·Tiziana LarussaFrancesco Luzza
Jan 12, 2019·Critical Reviews in Food Science and Nutrition·Sita Sharan PatelPriyal Jain
Apr 3, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Seyede Sara SeyedizadeAmir Hossein Abdolghaffari
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sun Young MoonCheol Hwangbo
Dec 17, 2019·Current Pharmaceutical Biotechnology·Mehdi ZobeiriSeyed Mohammad Nabavi
Aug 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaoming LiMiaoxian Dong

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