A Mechanistic Study to Determine the Structural Similarities Between Artificial Membrane Strat-M™ and Biological Membranes and Its Application to Carry Out Skin Permeation Study of Amphotericin B Nanoformulations

AAPS PharmSciTech
Lakhvir KaurSubheet Kumar Jain

Abstract

Type of biological membrane used in skin permeation experiment significantly affects skin permeation and deposition potential of tested formulations. In this study, a comparative study has been carried out to evaluate the potential of a synthetic membrane (Strat-M™) with rat, human, and porcine ear skin to carry out skin permeation study of nanoformulations of a high molecular weight drug, amphotericin B. Results demonstrated that the permeation of this high molecular weight drug through Strat-M™ showed close similitude to human skin. Value of correlation coefficient (R2) of log diffusion between Strat-M™ and human skin was found to be 0.99 which demonstrated the similarities of Strat-M™ membrane to the human skin. In similarity factor analysis, the value of f2 was also found to be 85, which further demonstrated the similarities of Strat-M™ membrane to human skin. Moreover, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller (BET) analysis of synthetic and biological membranes depicted almost similar morphological features (thickness, pore size, surface morphology, and diameter) of synthetic membrane with human skin. The results of the study demonstrated Strat-M™ as a better al...Continue Reading

References

Aug 1, 1992·The Journal of Pharmacy and Pharmacology·Y MorimotoH Omiya
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·I P Dick, R C Scott
Apr 1, 1995·Clinical Microbiology Reviews·I Weitzman, R C Summerbell
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·K MaebashiH Yamaguchi
May 30, 2002·Pharmaceutical Research·Afsaneh LavasanifarGlen S Kwon
Mar 8, 2003·International Journal of Pharmaceutics·N CoceaniM Grassi
Jan 26, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ute JacobiJuergen Lademann
Jan 10, 2008·AAPS PharmSciTech·Francesco CilurzoChiara Sinico
Nov 18, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ana M Barbero, H Frederick Frasch
Mar 9, 2010·Expert Opinion on Drug Delivery·Mikolaj MilewskiAudra L Stinchcomb
Apr 21, 2012·Journal of Biomedical Nanotechnology·Cristiane Moraes SantosLucas Antônio Miranda Ferreira
Jan 15, 2013·ISRN Pharmaceutics·D Prasanthi, P K Lakshmi
Feb 27, 2013·International Journal of Pharmaceutics·Dolores R SerranoJuan J Torrado
Oct 19, 2013·International Journal of Dermatology·Gülgün YenişehirliYunus Bulut
Nov 1, 2013·Anais Brasileiros De Dermatologia·Maria Fernanda Reis Gavazzoni DiasDavid Rubem Azulay
Dec 24, 2013·Drug Delivery·Mohammed Shafik El-RidyMarwa Hasanin Asfour
Oct 28, 2014·Journal of Applied Toxicology : JAT·Eui Chang Jung, Howard I Maibach
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Takashi UchidaKenji Sugibayashi
Dec 4, 2014·Molecular Immunology·Artur SummerfieldMeret E Ricklin
Dec 31, 2014·Journal of Liposome Research·Lakhvir KaurDeepika Sharma
Feb 13, 2015·SpringerPlus·Vikesh Kumar Bhatia, Prakash Chand Sharma
Apr 26, 2015·International Journal of Pharmaceutics·Cedar H A BoakyeMandip Singh
Aug 11, 2015·International Journal of Pharmaceutical Investigation·Pawan KumarPriti Girotra

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Citations

Apr 17, 2019·Pharmaceutics·Dolores R SerranoJuan José Torrado
Oct 22, 2019·Journal of Liposome Research·Manjot KaurSubheet Kumar Jain
Sep 12, 2019·Journal of Microencapsulation·Subheet Kumar JainNeha Panchal
Oct 18, 2019·Future Medicinal Chemistry·Hongmei XuZhimei Song
Jul 31, 2020·Pharmaceuticals·Pratheeksha Koppa RaghuNeelesh Kumar Mehra
Jan 21, 2021·Pharmaceutics·Ositomiwa O OsipitanAnthony J Di Pasqua
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan
Aug 19, 2020·ACS Infectious Diseases·Raquel Fernández-GarcíaDolores R Serrano
Oct 29, 2021·Frontiers in Pharmacology·Daniele Carvalho AbrantesLeonardo Fernandes Fraceto

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Methods Mentioned

BETA
dissection
ELISA

Software Mentioned

Strat
[UNK]
Sigma stat
STATCON

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