A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading

Biomechanics and Modeling in Mechanobiology
Mansoor A HaiderF Guilak

Abstract

The chondron is a distinct structure in articular cartilage that consists of the chondrocyte and its pericellular matrix (PCM), a narrow tissue region surrounding the cell that is distinguished by type VI collagen and a high glycosaminoglycan concentration relative to the extracellular matrix. We present a theoretical mechano-chemical model for the passive volumetric response of an isolated chondron under osmotic loading in a simple salt solution at equilibrium. The chondrocyte is modeled as an ideal osmometer and the PCM model is formulated using triphasic mixture theory. A mechano-chemical chondron model is obtained assuming that the chondron boundary is permeable to both water and ions, while the chondrocyte membrane is selectively permeable to only water. For the case of a neo-Hookean PCM constitutive law, the model is used to conduct a parametric analysis of cell and chondron deformation under hyper- and hypo-osmotic loading. In combination with osmotic loading experiments on isolated chondrons, model predictions will aid in determination of pericellular fixed charge density and its relative contribution to PCM mechanical properties.

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Citations

Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Dec 3, 2008·Journal of Biomechanical Engineering·Holly A LeddyFarshid Guilak
Sep 8, 2010·Journal of Biomechanical Engineering·Tracy A PowellVictor H Barocas
Jul 31, 2008·PloS One·Gidon OfekKyriacos A Athanasiou
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christopher J O'ConorFarshid Guilak
Jul 20, 2012·Annual Review of Biomedical Engineering·G A Ateshian, J D Humphrey
Sep 4, 2014·Current Rheumatology Reports·Johannah Sanchez-AdamsFarshid Guilak
Aug 21, 2012·Mechanics Research Communications·Gerard A AteshianClark T Hung
Aug 31, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Rebecca E WiluszFarshid Guilak
Oct 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mehdi KhoshgoftarSuzanne A Maher
Aug 12, 2018·Journal of Biomechanical Engineering·Jay C HouGerard A Ateshian
Jun 19, 2013·Journal of Biomechanical Engineering·Gerard A AteshianJeffrey A Weiss
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May 26, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Farshid GuilakIngrid Meulenbelt
Jul 3, 2021·Advanced Functional Materials·Claudia LoebelJason A Burdick

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