A medical mystery of complex regional pain syndrome

Heliyon
Jabril EldufaniGilbert A Blaise

Abstract

Complex regional pain syndrome (CRPS) is a condition of neuropathic pain, which is characterized by significant autonomic and inflammatory features. CRPS occurs in patients who have limb surgery, limb fractures, or trauma. Many patients may have pain resolve within twelve months of the inciting incident; however, a small subset progresses to the chronic form. This transitional process often happens by changing from warm CRPS with dominant inflammatory phase to cold CRPS, in which autonomic characteristics or manifestations dominate. Several peripheral and central mechanisms are involved, which might vary among individuals over a period of time. Other contributors include peripheral and central sensitization, autonomic alterations, inflammatory and immune changes, neurochemical changes, and psychological and genetic factors. Although effective management of the chronic CRPS form is often challenging, there are a few high quality randomized controlled trials that support the efficacy of the most commonly used therapeutic approaches.

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Citations

Oct 30, 2020·Frontiers in Pharmacology·Francisco Rafael NietoMilica S Prostran
Jan 30, 2021·Curēus·Raj H PatelNir Hus
Feb 15, 2021·Neuroscience and Biobehavioral Reviews·Élora MidavainePhilippe Sarret
Mar 18, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Imogene MundayToby Newton-John
Apr 1, 2021·Molecular Pain·Amrita Prasad Md, Krishnan Chakravarthy Md
Mar 29, 2021·Neuroscience and Biobehavioral Reviews·Christine B SiebergIgor Elman
May 13, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Simone SchiavoRita Katznelson
May 10, 2021·International Journal of Surgery Case Reports·Luxwell JokonyaKazadi K N Kalangu
Jun 25, 2021·Pain and Therapy·Samantha-Su TaylorOmar Viswanath
Jul 3, 2021·Entropy·Stephen Fox

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Methods Mentioned

BETA
biopsies
biopsy
pharmacotherapy

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