A medullary dorsal horn relay for the cardiorespiratory responses evoked by stimulation of the nasal mucosa in the muskrat Ondatra zibethicus: evidence for excitatory amino acid transmission

Brain Research
W M Panneton, P Yavari

Abstract

Stimulation of the upper respiratory tract, including the nasal mucosa, with water, vaporous irritants, or gases, induces a collation of several cardiorespiratory responses including an apnea and bradycardia and often some change in arterial blood pressure. Since the nasal mucosa is innervated by branches of the trigeminal nerve, it implies that some part of the trigeminal system within the central nervous system mediates the autonomic responses induced by nasal stimulation. In the present study, respirations, heart rate and arterial pressure were monitored in muskrats anesthetized with a mixture of chloralose-urethane. We induced a bradycardia and apnea by stimulating the nasal mucosa of muskrats with brief (5 s) transnasal application of vapors of ammonia hydroxide. In an effort to determine the central site where the trigeminal mediation of the cardiorespiratory responses occurs, small nanoliter injections of 2% lidocaine were made bilaterally into the subnucleus caudalis of the spinal trigeminal nucleus (referred to as the medullary dorsal horn) to determine if the responses could be blocked. The responses could be blocked when the lidocaine injections on both sides were placed in the rostral, ventral parts of the medullary...Continue Reading

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Citations

Aug 14, 2010·Journal of Applied Physiology·W Michael PannetonThomas E Dahms
Jan 23, 2010·Journal of Applied Physiology·W Michael PannetonRajko Juric
Sep 22, 2007·AJNR. American Journal of Neuroradiology·X LvZ Wu
Jul 20, 2010·Autonomic Neuroscience : Basic & Clinical·Ariadiny Lima CaetanoHudson Sousa Buck
Sep 24, 2008·Autonomic Neuroscience : Basic & Clinical·W Michael PannetonQi Gan
Nov 3, 2004·Respiratory Physiology & Neurobiology·Mingchen JiangDonald R McCrimmon
Dec 14, 2011·Respiratory Physiology & Neurobiology·W Michael PannetonD Wei Sun
Feb 22, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B J Sessle
Jun 23, 2009·Journal of Neurosurgical Anesthesiology·Bernhard SchallerUNKNOWN Trigemino-Cardiac Reflex Examination Group (TCREG)
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei Sun, W Michael Panneton
May 25, 2002·Canadian Journal of Physiology and Pharmacology·Hudson de Sousa BuckRéjean Couture
Jun 26, 2020·Frontiers in Neuroscience·W Michael Panneton, Qi Gan
Nov 7, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miroslav RozloznikMathias Dutschmann
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Pedro Boscan, Julian F R Paton
Apr 10, 2010·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·X LvZ Wu

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