A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells

PloS One
D AssentErik Maquoi

Abstract

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we have previously demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. Here we performed a transcriptomic analysis to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was perform...Continue Reading

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Citations

Dec 10, 2015·Survey of Ophthalmology·Jin-Hong ChangDimitri T Azar
Mar 26, 2016·Frontiers in Pharmacology·Hassan RammalHamid Morjani
Apr 28, 2018·Cell Adhesion & Migration·Elodie HenrietFrédéric Saltel
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Apr 10, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·S Pauliina TurunenKaisa Lehti

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Datasets Mentioned

BETA
GSE49595

Methods Mentioned

BETA
flow cytometry
chip
in vitro transcription
FACS
ELISA
fluorescence-activated cell sorting

Software Mentioned

DAVID
Chipster
BeadStudio
Ingenuity Pathways Analysis ( IPA )
IPA
R package lumi Chipster
GraphPad Prism
R package lumi
ModFit LT

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