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A membranotropic region in the C-terminal domain of hepatitis C virus protein NS4B interaction with membranes

Biochimica Et Biophysica Acta

Jul 28, 2009

Jaime GuillénJosé Villalaín

Abstract

We have identified a membrane-active region in the HCV NS4B protein by studying membrane rupture induced by a NS4B-derived peptide library on model membranes. This segment corresponds to one of two previously predicted amphipathic helix and define it as a new membrane association domain...read more

Mentioned in this Paper

Tissue Membrane
Molecular Helix
Carboxy-Terminal Amino Acid
Viral Nonstructural Proteins NS2
Virion
Tertiary Protein Structure
Helix (Snails)
Fluorescence
Plasma Protein Binding Capacity
Tetraiodofluorescein
1
18
Paper Details
References
  • References52
  • Citations5
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  • References52
  • Citations5
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A membranotropic region in the C-terminal domain of hepatitis C virus protein NS4B interaction with membranes

Biochimica Et Biophysica Acta

Jul 28, 2009

Jaime GuillénJosé Villalaín

PMID: 19631190

DOI: 10.1016/j.bbamem.2009.07.011

Abstract

We have identified a membrane-active region in the HCV NS4B protein by studying membrane rupture induced by a NS4B-derived peptide library on model membranes. This segment corresponds to one of two previously predicted amphipathic helix and define it as a new membrane association domain...read more

Mentioned in this Paper

Tissue Membrane
Molecular Helix
Carboxy-Terminal Amino Acid
Viral Nonstructural Proteins NS2
Virion
Tertiary Protein Structure
Helix (Snails)
Fluorescence
Plasma Protein Binding Capacity
Tetraiodofluorescein
1
18

Similar Papers Found In These Feeds

Hepatitis C

Hepatitis C virus causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Discover the latest research on Hepatitis C here.

Related Papers

Biochimica Et Biophysica Acta

Membrane interaction of segment H1 (NS4B(H1)) from hepatitis C virus non-structural protein 4B

Biochimica Et Biophysica ActaJanuary 5, 2011
M Francisca Palomares-Jerez, José Villalaín
Biochimica Et Biophysica Acta

Biophysical characterization of the fusogenic region of HCV envelope glycoprotein E1

Biochimica Et Biophysica ActaAugust 25, 2009
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Paper Details
References
  • References52
  • Citations5
12345...
  • References52
  • Citations5
1
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