A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2

Cells
Nina-Naomi KreisJuping Yuan

Abstract

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to a higher rate of pregnancy complications, including preterm births, miscarriage, and stillbirth. Despite reports of neonatal COVID-19, definitive proof of vertical transmission is still lacking. In this review, we summarize studies regarding the potential evidence for transplacental transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterize the expression of its receptors and proteases, describe the placental pathology and analyze virus-host interactions at the maternal-fetal interface. We focus on the syncytium, the barrier between mother and fetus, and describe in detail its physical and structural defense against viral infections. We further discuss the potential molecular mechanisms, whereby the placenta serves as a defense front against pathogens by regulating the interferon type III signaling, microRNA-triggered autophagy and the nuclear factor-κB pathway. Based on these data, we conclude that vertical transmission may occur but rare, ascribed to the potent physical barrier, the fine-regulated placental immune defense and modulation str...Continue Reading

References

Jul 14, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C D OcklefordR A Badley
Jul 1, 1995·Immunobiology·S SchützeM Krönke
Nov 1, 1996·American Journal of Reproductive Immunology : AJRI·A MalekH Schneider
Oct 19, 1999·Molecular and Cellular Biology·E J SmartM P Lisanti
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Dec 17, 2002·Nature Immunology·Sergei V KotenkoRaymond P Donnelly
Jul 11, 2003·Placenta·E A LintonC W G Redman
Jan 13, 2004·Human Reproduction Update·A MalassinéD Evain-Brion
Mar 27, 2004·Nature Reviews. Microbiology·Dimiter S Dimitrov
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Wei LiJohn R G Challis
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vikki M AbrahamsGil Mor
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Ryan E Longman, Timothy R B Johnson
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
Jul 5, 2007·Nature Reviews. Molecular Cell Biology·Satyajit Mayor, Richard E Pagano
Aug 19, 2007·Nature Reviews. Immunology·Derry C Roopenian, Shreeram Akilesh
Nov 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liomar A A NevesK Bridget Brosnihan
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu HuangDa-Jin Li
Mar 12, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Johanne Holm ToftRigmor Austgulen
Jul 22, 2008·Journal of Clinical Pathology·D J Roberts, M D Post
Jul 25, 2008·Biology of Reproduction·Chie-Pein ChenHungwen Chen
Mar 7, 2009·Biochimica Et Biophysica Acta·Sanae Shoji-Kawata, Beth Levine
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Jan 9, 2010·American Journal of Reproductive Immunology : AJRI·Irit Manaster, Ofer Mandelboim
Jan 26, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xue-Jun LvGui-Sheng Qian
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Andrew N SharpGil Mor
May 7, 2010·Protoplasma·Jennifer A ThorleyJoshua Zachary Rappoport
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Feb 1, 2011·Journal of Reproductive Immunology·Vikki M Abrahams
Feb 12, 2011·Cell Death and Differentiation·R KangD Tang
Mar 16, 2011·Annals of the New York Academy of Sciences·Gil MorSeth Guller
Jul 26, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sanjay BatraMalaya K Sahoo

❮ Previous
Next ❯

Citations

Sep 25, 2020·Physiological Reviews·Elizabeth A N WastnedgeHilary O D Critchley
Dec 5, 2020·Viruses·Hanna HenzingerMartin Pichler
Mar 7, 2021·International Journal of Molecular Sciences·Evgeniya E BurkovaGeorgy A Nevinsky
Feb 28, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·M ZaighamP Tannenberg
Apr 4, 2021·International Journal of Molecular Sciences·Kavita NarangRegan N Theiler
Apr 11, 2021·Journal of Osteopathic Medicine·Nicholas B SajjadiMicah Hartwell
Apr 20, 2021·Journal of Molecular Histology·Shahrzad AghaamooMojgan Rahmanian
Jun 3, 2021·International Journal of Molecular Sciences·Iwona Bukowska-OśkoPaweł Kowalczyk
Jun 1, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Verónica Zaga-ClavellinaDaniel Ortuño-Sahagún
Jun 11, 2021·The American Journal of Pathology·Arthur ColsonFrédéric Debiève
Jun 12, 2021·Der Pathologe·T MenterE Bruder
Jul 15, 2021·Scientific Reports·Mirella MouradYoel Sadovsky
Sep 21, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jessica A MeyerChristina A Penfield

❮ Previous
Next ❯

Methods Mentioned

BETA
scRNA-seq
transmission electron microscopy

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

© 2021 Meta ULC. All rights reserved