The clinical effect of cerebral microbleeds (CMBs) on cognition has been receiving much research attention, but results are often inconsistent. We searched PubMed, Embase, Web of Science, and some Chinese electronic databases. A total of 15 studies were included. Patients with CMBs had higher incidence of cognitive dysfunction (OR 3.14; 95% CI 1.66-5.92) and lower scores of cognitive function (SMD was -0.36 [-0.55, -0.18] in the MMSE group and -0.65 [-0.99, -0.32] in the MoCA [Montreal Cognitive Assessment] group). The results also indicated that a higher number of CMB lesions led to more severe cognitive dysfunction (SMD was -2.41 [-5.04, -0.21] in the mild group and -2.75 [-3.50, -2.01] in the severe group). We also found that cognitive performance was significantly impaired when CMBs were located in deep (-0.4 [-0.69, -0.11]), lobar regions (-0.50 [-0.92, -0.09]), basal ganglia (-0.72 [-1.03, -0.41]), and thalamus brain regions (-0.65 [-0.98, -0.32]). This meta-analysis showed that CMBs were associated with cognitive dysfunction according to higher number and different locations of CMBs. Future work should focus on long-term prognosis of continuing cognitive decline and specific treatments to reduce the formation of CMBs.
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Letter by Rodríguez-García and Rodríguez-García [corrected] regarding article, "Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association"
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Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.