A meta-analysis of clinical studies of statins for prevention of abdominal aortic aneurysm expansion

Journal of Vascular Surgery
Hisato TakagiTakuya Umemoto

Abstract

Despite the absence of a relationship between cholesterol and abdominal aortic aneurysm (AAA) expansion, there is evidence from a number of studies to suggest that statin therapy may influence AAA expansion, presumably through pleiotropic effects. To confirm whether statin therapy is associated with less AAA expansion, we performed a meta-analysis of clinical controlled studies of statin therapy for prevention of AAA expansion. To identify all clinical studies of statin therapy vs control (no statins) enrolling patients with small (≤ 55 mm) AAA, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. For each study, data regarding AAA expansion in both the statin and control groups were used to generate standardized mean differences (SMDs; <0 favoring statin therapy; >0 favoring control) and 95% confidence intervals (CIs). Study-specific estimates were combined using inverse variance-weighted averages of logarithmic SMDs in fixed-effects and random-effects models. We identified five clinical controlled studies of statin therapy vs control enrolling patients with small AAA, including no randomized and five observational studies. Our meta-analysis included data on 697 patients with small AAA receive...Continue Reading

References

Mar 10, 1997·FEBS Letters·P F LiR von Harsdorf
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Jul 13, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·W R W WilsonM M Thompson
Jan 18, 2006·Journal of Vascular Surgery·Arun KalyanasundaramDavid J Carey
Mar 8, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·O SchoutenD Poldermans
Jun 19, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J EvansM M Thompson
Apr 9, 2008·Circulation·B Timothy BaxterRonald L Dalman
Apr 24, 2008·Interactive Cardiovascular and Thoracic Surgery·Martti MosorinFausto Biancari
Jan 3, 2009·Journal of Vascular Surgery·Hisato TakagiTakuya Umemoto
Jan 3, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L KarlssonH Pärsson
May 21, 2009·Cardiovascular Research·Takashi Miyake, Ryuichi Morishita
Dec 8, 2009·BMC Medical Research Methodology·Byron C WallaceThomas A Trikalinos

❮ Previous
Next ❯

Citations

Jul 27, 2012·Current Atherosclerosis Reports·Hong LuAlan Daugherty
Mar 14, 2014·Cardiovascular Research·Emil KozarovLina Badimon
May 21, 2015·International Journal of Molecular Sciences·Albert M Kroon, Jan-Willem Taanman
May 21, 2015·International Journal of Molecular Sciences·Koichi YoshimuraKimikazu Hamano
Dec 24, 2015·Clinical Cardiology·Alexander P TaylorJyothy J Puthumana
Jul 17, 2012·Annals of Vascular Surgery·Helena Kuivaniemi, James R Elmore
Jan 11, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Balachundar SubramaniamJohn G T Augoustides
Jun 30, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Kimon BekelisNancy E Morden
Oct 12, 2015·International Journal of Cardiology·Joaquin De HaroFrancisco Acin
Oct 1, 2011·Journal of Cardiac Surgery·Tom P TheruvathJohn S Ikonomidis
Mar 31, 2012·Journal of Vascular Surgery·Maxime RauxJean-Pierre Becquemin
Oct 22, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Vega de Céniga
Apr 6, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A Piechota-PolanczykM Klinger
May 18, 2011·Journal of Vascular Surgery·Craig D FergusonJonathan Golledge
May 15, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R J Darwood, M J Brooks
Jul 25, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Jul 27, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Vega de Céniga
Oct 9, 2012·International Journal of Cardiology·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Jan 11, 2011·Journal of Vascular Surgery·Kosmas I ParaskevasFrank J Veith
Dec 19, 2013·Vascular and Endovascular Surgery·Cleona GrayCiarán O McDonnell
Apr 1, 2012·Journal of Primary Care & Community Health·Andreas FrechMichael Schirmer
Sep 28, 2017·Journal of Cardiovascular Pharmacology·Shi-Lan ZhangLing Liu
Aug 25, 2017·Vascular Medicine·Sven Ross Mathisen, Michael Abdelnoor
Jan 25, 2012·Current Treatment Options in Cardiovascular Medicine·Reena L Pande
Apr 25, 2012·Current Opinion in Cardiology·Kosmas I ParaskevasDimitri P Mikhailidis
Jun 2, 2015·Expert Review of Cardiovascular Therapy·Jan H N Lindeman
Apr 8, 2018·General Thoracic and Cardiovascular Surgery·Naoki MasakiUNKNOWN STANP trial investigators
Oct 14, 2011·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Tjun Y Tang, Jonathan R Boyle
Oct 30, 2018·Journal of the American Heart Association·Konrad SalataMohammed Al-Omran
Nov 9, 2021·Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital·Bogdan A KindzelskiEric E Roselli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.