A meta-analysis of dexamethasone for pain management in patients with total knee arthroplasty

Medicine
Guanghong ZhouHao Jiang

Abstract

Pain management after a total-knee arthroplasty (TKA) has become an important issue in the field of medicine. This study conducted a meta-analysis from randomized controlled trials (RCTs) to assess the efficacy and safety of dexamethasone for pain management after TKA. PubMed, Medline, Embase, ScienceDirect, and the Cochrane Library were searched up to December 2017 for comparative RCTs involving dexamethasone and placebo for pain control after TKA. Primary outcomes were postoperative pain scores and opioid consumption. Secondary outcomes were length of hospital stay, adverse effects, and postoperative complications. We assessed statistical heterogeneity for each RCT with the use of a standard Chi-squared test and the I statistic. All data were carried out with Stata 14.0 software. A total of 6 RCTs were included. The present meta-analysis indicated that there were significant differences between dexamethasone-treated groups and placebo groups regarding postoperative pain scores at 12, 24, and 48 hours after TKA. Administering dexamethasone could significantly reduce opioid consumption at 12 hours after TKA. However, no significant difference was found in opioid consumption at 24 and 48 hours after TKA. There was a decreased ri...Continue Reading

References

Apr 4, 2002·The Journal of the American Academy of Orthopaedic Surgeons·Raymond S SinatraArsenio M Bustos
Jan 11, 2007·Scandinavian Journal of Immunology·G L BjornssonB Gudbjornsson
Nov 16, 2010·Anesthesiology Clinics·Pamela P Palmer, Ronald D Miller
May 17, 2012·Orthopedics·Morteza MeftahChitranjan S Ranawat
May 25, 2012·Orthopaedic Nursing·Cynthia LewisKathleen Bobay
Jan 12, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Masahiko IkeuchiToshikazu Tani
May 7, 2013·Clinical Orthopaedics and Related Research·In Jun KohTae Kyun Kim
Aug 8, 2014·Journal of Pain & Palliative Care Pharmacotherapy·Sandra L Kane-GillJoseph F Dasta
Sep 26, 2014·Plastic and Reconstructive Surgery·Robert D FunkSatya Krishna Ramachandran
May 1, 2017·The Journal of Arthroplasty·Ronald E DelanoisMichael A Mont
Jul 19, 2017·The Journal of Knee Surgery·Randa K ElmallahMichael A Mont

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Citations

Sep 9, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Davide PrevitaliChristian Candrian
Feb 23, 2021·The Journal of Arthroplasty·Yehoshua GleicherJesse I Wolfstadt
Mar 10, 2021·The Journal of International Medical Research·Youguang ZhuoYiyuan Zhang
Jun 12, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Huiming PengWenda Wang

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Methods Mentioned

BETA
PCA
total hip arthroplasty

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