PMID: 9541155Apr 16, 1998Paper

A meta-analysis of eight randomized, double-blind, controlled clinical trials of mirtazapine for the treatment of patients with major depression and symptoms of anxiety

The Journal of Clinical Psychiatry
J Fawcett, R L Barkin

Abstract

Patients diagnosed with major depression and prominent symptoms of anxiety often have a poor prognosis for recovery. A meta-analysis was performed to assess the efficacy of mirtazapine in comparison with placebo and amitriptyline for the relief of anxiety/agitation or anxiety/somatization in patients with major depressive illness. A meta-analysis of eight randomized, double-blind, placebo-controlled clinical trials was conducted for 161 mirtazapine-treated and 132 placebo-treated patients with a DSM-III diagnosis of major depression, baseline Hamilton Rating Scale for Depression (HAM-D) scores > or = 18, and a baseline score > or = 6 for the sum of HAM-D items 9, 10, and 11 (anxiety/agitation). Four of the clinical trials included an amitriptyline control group (N = 92). Mirtazapine-treated patients demonstrated a statistically significant (p < or = .05) reduction in the sum of HAM-D items 9, 10, and 11 (anxiety/agitation) compared with placebo-treated patients at Weeks 1, 2, 4, and 6 and at the endpoint. There was no statistically significant difference between the mirtazapine- and amitriptyline-treated patients at Weeks 1, 3, 4, 5, and 6 and at the endpoint. Similar results were found for the analysis of the mean of HAM-D ite...Continue Reading

Citations

Jun 28, 2003·Current Pain and Headache Reports·Paul D Thielking
May 25, 2005·Clinics in Geriatric Medicine·Robert L BarkinDiana S Barkin
May 17, 2005·Neuroscience and Biobehavioral Reviews·Alan Frazer, David A Morilak
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Paul E Holtzheimer, Charles B Nemeroff
Apr 23, 2003·Biological Psychiatry·K Ranga Rama Krishnan
Jan 5, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·P JollietM Bourin
Aug 17, 2006·Primary Care Companion to the Journal of Clinical Psychiatry·Prakash S MasandAshwin A Patkar
Nov 10, 2006·Journal of Affective Disorders·Uriel Halbreich, Linda S Kahn
Mar 28, 2013·Human Psychopharmacology·Dan J SteinSidney H Kennedy
Jul 25, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies of Biological Psychiatry. Task Force on Unipolar Depressive Disorders
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Paul E Holtzheimer, Charles B Nemeroff
Sep 1, 2002·Expert Review of Neurotherapeutics·David BaldwinAndrew Mayers
Nov 20, 2001·International Clinical Psychopharmacology·M L BoshuisenJ A den Boer
Nov 1, 2002·International Clinical Psychopharmacology·J F Van VeenH G M Westenberg
Oct 31, 2002·Human Psychopharmacology·Alan F Schatzberg
Aug 21, 2004·Journal of Child and Adolescent Psychopharmacology·Kirsi-Maria Haapasalo-PesuMauri Marttunen
Sep 7, 2006·International Journal of Geriatric Psychiatry·J Craig NelsonUNKNOWN Mirtazapine Nursing Home Study Group
Jan 15, 2002·Journal of Women's Health & Gender-based Medicine·H JoffeC Soares
Oct 11, 2001·Journal of Clinical Psychopharmacology·L M KoranM Elliott
Apr 25, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN WFSBP Task Force on Unipolar Depressive Disorders
Jun 1, 2006·Acta Neuropsychiatrica·Luis San, Belen Arranz
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies Biological Psychiatry Task Force on Treatment Guidelines for Unipolar Depressive Disorders
Apr 19, 2000·Journal of Clinical Psychopharmacology·A J Elliott, P P Roy-Byrne
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Jennifer R Evans

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