A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model

Frontiers in Immunology
Mizuho FukushigeFrancisca Mutapi

Abstract

Schistosomiasis is a water-borne, parasitic disease of major public health importance. There has been considerable effort for several decades toward the development of a vaccine against the disease. Numerous mouse experimental studies using attenuated Schistosoma mansoni parasites for vaccination have been published since 1960s. However, to date, there has been no systematic review or meta-analysis of these data. The aim of this study is to identify measurable experimental conditions that affect the level of protection against re-infection with S. mansoni in mice vaccinated with radiation attenuated cercariae. Following a systematic review, a total of 755 observations were extracted from 105 articles (published 1963-2007) meeting the searching criteria. Random effects meta-regression models were used to identify the influential predictors. Three predictors were found to have statistically significant effects on the level of protection from vaccination: increasing numbers of immunizing parasites had a positive effect on fraction of protection whereas increasing radiation dose and time to challenge infection had negative effects. Models showed that the irradiated cercariae vaccine has the potential to achieve protection as high a...Continue Reading

References

Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthJ H Ouma
Jul 1, 1971·Journal of Gerontology·R R Kohn
Feb 1, 1983·Experimental Parasitology·D A Dean
Aug 1, 1981·Experimental Parasitology·S Y HsüL F Burmeister
Dec 5, 1998·International Journal of Epidemiology·M BöttigerA Svensson
Nov 5, 1999·Nature Medicine·M E Woolhouse, P Hagan
Dec 22, 1999·Microbes and Infection·R A Wilson, P S Coulson
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shane CrottyRafi Ahmed
May 8, 2004·Seminars in Immunology·Shane Crotty, Rafi Ahmed
Oct 27, 2004·Molecular and Biochemical Parasitology·Rachel S CurwenR Alan Wilson
Sep 6, 2005·Parasite Immunology·J P HewitsonA P Mountford
Jun 23, 2006·Infection and Immunity·Thomas M KariukiPatricia S Coulson
Aug 23, 2006·Infection and Immunity·Tjalling LeenstraJennifer F Friedman
Oct 17, 2006·Parasitology Today·N R Bergquist, D G Colley
Jan 26, 2008·Nature Reviews. Immunology·John T Harty, Vladimir P Badovinac
Mar 7, 2008·Chronic Illness·Charles H King, Madeline Dangerfield-Cha
May 20, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·N MidziT Mduluza
Jul 31, 2008·PLoS Neglected Tropical Diseases·Fred A LewisMatty Knight
Mar 19, 2009·Parasite Immunology·M L BurkeD P McManus
Jul 31, 2009·The New England Journal of Medicine·Meta RoestenbergRobert Sauerwein
Aug 27, 2009·PLoS Neglected Tropical Diseases·Peter J Hotez, Aruna Kamath
Aug 14, 2010·The Lancet Infectious Diseases·Darren J GrayAllen G Ross
Oct 30, 2010·Immunity·Federica SallustoRafi Ahmed
Oct 27, 2011·PLoS Computational Biology·Kate M MitchellMark E J Woolhouse
Apr 11, 2012·Parasite Immunology·Hamish E G McWilliamE N T Meeusen
Aug 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kate M MitchellMark E J Woolhouse
Feb 19, 2013·Trends in Parasitology·Francisca MutapiW Evan Secor

❮ Previous
Next ❯

Citations

Aug 19, 2015·Frontiers in Immunology·Rashika El RidiDonald P McManus
Nov 24, 2018·Parasite Immunology·Mizuho FukushigeMark E J Woolhouse
Feb 23, 2020·Seminars in Immunopathology·Donald P McManusHong You
Oct 8, 2016·Parasites & Vectors·Biniam Mathewos TebejeDonald P McManus

❮ Previous
Next ❯

Methods Mentioned

BETA
chemical treatment
transgenic

Software Mentioned

GraphPad Prism
OvidSP
GraphPad
ProQuest Full Text
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.