A meta-analysis of negative symptoms in dual diagnosis schizophrenia

Psychological Medicine
S PotvinE Stip

Abstract

According to the self-medication hypothesis, schizophrenia patients would abuse psychoactive substances to get a relief from their negative symptoms. Studies testing the self-medication hypothesis in dual diagnosis (DD) schizophrenia have not been conclusive, with some studies showing that DD patients experience fewer negative symptoms, whereas other studies have failed to detect such differences. One potential confounding factor for this discrepancy lies in the diverse scales used to evaluate the negative symptoms. A systematic quantitative review of the literature using computerized search engines has been undertaken. Studies were retained in the analysis if: (i) they assessed negative symptoms using the SANS; (ii) groups of schizophrenia patients were divided according to substance use disorders (alcohol, amphetamines, cannabis, cocaine, hallucinogens, heroin and phencyclidine). Attainable published studies were screened. According to our inclusion criteria, 18 possible studies emerged. Data from 11 studies were available for mathematical analysis. A moderate effect size (total n = 1135, 451 DD, 684 single diagnosis, adjusted Hedges' g = -0.470, p = 0.00001) was obtained, within a random-effect model, suggesting that DD pati...Continue Reading

Citations

Dec 12, 2007·Psychological Medicine·P A RingenO A Andreassen
Jul 16, 2008·Cognitive Neuropsychiatry·Stéphane PotvinEmmanuel Stip
Jul 10, 2010·Substance Abuse Treatment, Prevention, and Policy·Chaturaka RodrigoSenaka Rajapakse
Jul 1, 2009·Indian Journal of Psychological Medicine·Chaturaka Rodrigo, Senaka Rajapakse
Aug 4, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Alex J MitchellMaria Rizzo
Jan 30, 2013·Journal of Substance Abuse Treatment·Thomas O'Hare, Ce Shen
Sep 16, 2014·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Giuseppe CarràMassimo Clerici
Jan 19, 2016·L'Encéphale·N SimonJ-M Azorin
May 1, 2007·Behaviour Research and Therapy·Nicholas TarrierUNKNOWN Socrates Trial Group
Apr 10, 2013·Neuroscience and Biobehavioral Reviews·Enoch NgJohn C Roder
Jul 20, 2011·Journal of Psychopharmacology·Marise MachielsenInez Myin-Germeys
Mar 5, 2014·The Australian and New Zealand Journal of Psychiatry·Matthew LargeOlav Nielssen
Sep 11, 2007·The Australian and New Zealand Journal of Psychiatry·Stéphane PotvinEmmanuel Stip
Apr 5, 2012·The Australian and New Zealand Journal of Psychiatry·Elizabeth MooreDavid J Castle
Apr 21, 2009·Acta Psychiatrica Scandinavica·J KoskinenJ Miettunen
Mar 1, 2015·Irish Journal of Psychological Medicine·J P LyneM Clarke
May 6, 2014·European Archives of Psychiatry and Clinical Neuroscience·Inge GoryniaAndreas Heinz
Jul 31, 2013·Psychiatry and Clinical Neurosciences·Patrizia Thoma, Irene Daum
Sep 2, 2008·Acta Psychiatrica Scandinavica·P A RingenO A Andreassen
Sep 30, 2019·European Archives of Psychiatry and Clinical Neuroscience·Alkomiet HasanEva Hoch
Dec 29, 2007·The American Journal of Drug and Alcohol Abuse·Stéphane PotvinAlain Gendron
Mar 17, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthias KirschnerAlain Dagher

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