A meta-analysis of neurocognition in youth with familial high risk for bipolar disorder

European Psychiatry : the Journal of the Association of European Psychiatrists
Emre Bora, A Özerdem

Abstract

Neuropsychological impairment, including deficits in social cognition is evident in subjects at genetic high-risk for psychosis. However, findings in youth at genetic risk to bipolar disorder (BP) have been suggested to be less supportive of premorbid deficits. We aimed to conduct a meta-analysis of cognitive deficits in youth with familiar risk for bipolar disorder (FHR-BD). A novel meta-analysis of FHR-BD (mean age 10-25), including 18 studies (786 offsprings/siblings of patients with BD and 794 healthy controls), was conducted. Both general cognition (d=0.29, CI=0.15-0.44) and social cognition (d=0.23, CI=0-0.45) were impaired in FHR-BD. In comparison to controls, FHR-BD had significant deficits in several cognitive domains, including visual memory (d=0.35), verbal memory (d=0.21), processing speed (d=0.26) and sustained attention (d=0.36). There was no significant difference between FHR-BD and controls in planning and working memory. Cognitive deficits are evident in individuals who are at genetic high-risk for developing BD. Neurodevelopmental abnormalities are likely playing a role not only in schizophrenia but also in BD.

References

May 7, 2002·Journal of Clinical and Experimental Neuropsychology·Patricia McDonough-RyanStephen M Strakowski
Aug 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Guy M GoodwinEduard Vieta
Nov 27, 2008·Acta Psychiatrica Scandinavica·A M McIntoshS M Lawrie
Dec 17, 2008·Psychological Medicine·A E DoyleJ Biederman
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Feb 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Nick Craddock, Michael J Owen
Feb 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·James H MacCabeChristina M Hultman
May 10, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vaibhav A DiwadkarMatcheri S Keshavan
Nov 6, 2012·Journal of Affective Disorders·Jane WhitneyKiki Chang
May 1, 2010·Therapeutic Advances in Chronic Disease·C T Sudhir Kumar, Sophia Frangou
Dec 26, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qing ZhaoRaymond C K Chan
Jan 23, 2013·International Journal of Adolescent Medicine and Health·Cheryl EngerAndrew T McAfee
Apr 5, 2013·Bipolar Disorders·Boris BirmaherDavid J Kupfer
May 24, 2013·JAMA Psychiatry·Raveen ParboosingAlan S Brown
Mar 8, 2014·Psychiatry Research·Tsutomu TakahashiChristos Pantelis
Apr 23, 2014·The British Journal of Clinical Psychology·Hana PavlickovaRichard P Bentall
Jul 14, 2014·Journal of Psychiatric Research·Rico S C LeeIan B Hickie
Jul 30, 2014·Psychological Medicine·E Bora
Jul 30, 2014·Psychological Medicine·K E LewandowskiD Ongür
Sep 28, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Emre Bora
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R VonkR S Kahn
Dec 3, 2014·Journal of Affective Disorders·David FreedmanCatherine A Schaefer
Sep 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elena de la SernaJosefina Castro-Fornieles
Dec 15, 2015·The American Journal of Psychiatry·Brett A ClementzCarol A Tamminga
Feb 14, 2016·Journal of Affective Disorders·Lindsay C HanfordGeoffrey B Hall
Apr 25, 2016·Psychiatry Research. Neuroimaging·Lindsay C HanfordGeoffrey B Hall
May 4, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Emre BoraSelim Tümkaya

❮ Previous
Next ❯

Citations

Jul 3, 2020·Journal of Child and Adolescent Psychopharmacology·Joshua V StreicherMelissa P DelBello
Feb 14, 2020·European Child & Adolescent Psychiatry·Jordi SolerMar Fatjó-Vilas
Aug 2, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·E Bora
Feb 10, 2021·European Child & Adolescent Psychiatry·Camilla Jerlang ChristianiJens Richardt Møllegaard Jepsen
Feb 5, 2021·Schizophrenia Research·Anna Hester Ver Loren van ThemaatSigne Vangkilde
Apr 6, 2021·Frontiers in Pediatrics·Myrthe G B M BoekhorstVeerle Bergink
May 29, 2021·International Journal of Bipolar Disorders·Riccardo GuglielmoGregor Hasler
Jul 14, 2021·Journal of Psychiatric Research·Sussy C LuperdiVicent Balanzá-Martínez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.