A meta-analysis of platinum plus gemcitabine or vinorelbine in the treatment of advanced non-small-cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Guanghui GaoQiong Zhan

Abstract

Whether platinum plus gemcitabine or vinorelbine are equally effective in the treatment of advanced non-small-cell lung cancer (NSCLC) is still controversial, a meta-analysis was performed to compare the gemcitabine plus platinum with vinorelbine plus platinum regimens in first-line treatment of advanced NSCLC. A literature search was performed in PubMed database, the Cochrane Central Register of Controlled Trials (CENTRAL) database, the Physician Data Query (PDQ) database, EMBASE and the American Society of Clinical Oncology (ASCO) annual meeting abstracts. The following keywords were used: "non small cell lung cancer," or "Carcinoma, Non-Small-Cell Lung". Reference lists of original articles and review articles were also examined. The published languages and years were not limited. The trials searched were evaluated for eligibility and quality, and then the data were abstracted and analyzed. Endpoints were overall survival, overall response, and toxicity. Statistical tests for heterogeneity were one-sided; statistical tests for effect estimates were two-sided. Nine randomized controlled trials involving 2186 patients were identified from 453 reports. They were all published as full-text articles. The intention-to-treatment (I...Continue Reading

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Citations

Dec 21, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Kim SeltingRajiv Dhand
Jul 17, 2009·Expert Opinion on Investigational Drugs·Teni Boulikas
Mar 31, 2010·Expert Opinion on Drug Safety·Maria Carmela PiccirilloAlessandro Morabito
Oct 15, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Athanasios G Pallis, Vassilis Georgoulias

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