A meta-analysis of published studies of endothelial dysfunction does not support its routine clinical use

International Journal of Clinical Practice
A CardonaK K Ray

Abstract

Endothelial dysfunction is a marker of future cardiovascular disease (CVD) risk, yet epidemiological studies have yielded inconsistent results. We therefore studied the association between endothelial dysfunction and CVD under diverse circumstances. Literature-based meta-analysis of prospective observational studies with ≥ 12 months of follow-up published in Medline and having information on endothelial function and CVD outcomes. Tabular data on participant characteristics, endothelial function assessments and incident CVD outcomes were abstracted from individual studies. Random-effects meta-analysis was used to quantify pooled associations, and I(2) statistic to evaluate between-study heterogeneity. Potential sources of heterogeneity were explored by subgroup analyses and meta-regression. Thirty five studies involving 17,206 participants met the inclusion criteria. During more than 80,000 person-years of observation, up to 2755 CVD events were accrued, yielding a pooled relative risk (RR) of 1.25 (95% confidence interval 1.15-1.35) for CVD comparing top (i.e. more severe) vs. bottom (less severe) third of endothelial dysfunction. There was significant between-study heterogeneity and evidence of publication bias. RRs varied imp...Continue Reading

References

Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Jul 29, 2000·The American Journal of Cardiology·T NeunteuflF Weidinger
Aug 7, 2002·Circulation·Julian P J HalcoxArshed A Quyyumi
Jun 24, 2003·The American Journal of Cardiology·Arshed A Quyyumi
Sep 19, 2003·Journal of the American College of Cardiology·Sammy Y ChanAndrew Ignaszewski
Oct 13, 2004·The American Journal of Cardiology·Folkert W AsselbergsRené A Tio
Apr 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Thomas HeitzerThomas Meinertz
Sep 20, 2005·Journal of the American College of Cardiology·Matthias FrickFranz Weidinger
Sep 20, 2005·Journal of the American College of Cardiology·Brigitte MeyerRudolf Berger
Jan 9, 2008·International Journal of Cardiology·Marco GuazziRoss Arena
Mar 8, 2008·Journal of the American College of Cardiology·Rosario RossiMaria Grazia Modena
Jul 16, 2008·Journal of Hypertension·M Lorenza MuiesanEnrico Agabiti-Rosei
Jan 24, 2009·Journal of the American College of Cardiology·Yoshinobu KittaKiyotaka Kugiyama
Apr 7, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Line Skjold UlriksenGorm B Jensen
Aug 4, 2010·Autoimmunity Reviews·S SitiaM Turiel
Mar 5, 2011·International Journal of Cardiology·Isao TakishimaKiyotaka Kugiyama
Mar 8, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mahmut Ilker YilmazJuan Jesus Carrero
Mar 21, 2012·Annals of Internal Medicine·Maryam KavousiJacqueline C M Witteman
Apr 25, 2012·Journal of Hypertension·Lorenzo GhiadoniFrancesco Cosentino

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Citations

May 27, 2015·International Journal of Clinical Practice·L D Ferguson, N Sattar
Jun 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarLuisa Costanzo
Feb 28, 2016·Circulation. Cardiovascular Imaging·Andrea Cardona, Giuseppe Ambrosio
Feb 28, 2016·Circulation. Cardiovascular Imaging·Micaela IantornoRobert G Weiss
Oct 6, 2018·Current Vascular Pharmacology·Goran KoracevicMilan Djordjevic

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