A meta-analysis of randomized controlled trials to compare long-term clinical outcomes of bioabsorbable polymer and durable polymer drug-eluting stents

European Heart Journal. Quality of Care & Clinical Outcomes
Naim MridhaKuljit Singh

Abstract

The durable polymer (DP) of a drug-eluting stent (DES) serves no function once drug elution is complete. To ascertain the benefits of bioabsorbable polymer (BP) over DP-DESs requires a longer follow-up period, to overcome the time taken for polymer absorption. The primary aim of this meta-analysis was to compare the safety and efficacy of BP-DES with the DP-DES over mid (2 years) to long-term (3-5 years) follow-up. A thorough computer-based search was performed using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases. We only included randomized controlled studies comparing clinical outcomes between BP-DESs and DP-DESs. Only studies where data were available for a minimum of 2 years were included. A separate analysis of 2-year outcomes and 3- to 5-year outcomes were conducted. Data from 6 and 8 studies were included in 3- to 5-year and 2-year follow-up, respectively. There were no differences between stent groups in cardiac mortality, stent thrombosis (ST), target lesion revascularization, target vessel failure, and reinfarction rates for either 2-year or 3- to 5-year follow-up. Subgroup analysis according to strut thickness (<100 µm, >100 µm) of BP-DES demonstrated similar results. The analyses of ST and very late ST f...Continue Reading

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Citations

Apr 9, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Davide Capodanno
Dec 11, 2019·BMJ : British Medical Journal·Mary Ellen McCann, Sulpicio G Soriano
Apr 16, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jorge Belardi, Pablo Lamelas
Jul 28, 2019·Nature Reviews. Cardiology·Sho ToriiAloke V Finn
Jan 19, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giuseppe Tarantini, Chiara Fraccaro
Jan 11, 2020·JACC. Cardiovascular Interventions·Stephan WindeckerYasushi Ueki
Mar 18, 2021·Journal of Biomechanical Engineering·Harry J CarpenterPeter J Psaltis
Apr 23, 2021·Expert Review of Cardiovascular Therapy·Tanveer MirLuis Afonso

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