A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis

Medicine
Shaojun LiLiping Tan

Abstract

To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT). A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically. However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0.94 [0.82-1.06] at day 28; 0.73 [0.36-1.47] at day 90; 1.16 [0.78-1.71] at 6 months; respectively). Selenium supplementation did not show favorable efficacy in the incidence of renal failure, secondary infection or duration of mechanical ventilation (RR [95% CI]: 0.65 [0.41-1.03]; 0.96 [0.87-1.06]; standard mean difference [SMD] [95% CI]: 0.17 [-0.30-0.63]; respectively). Interestingly, we found that selenium therapy was benefit for sepsis patients with reduced duration of vasopressor therapy, staying time in intensive care unit and hospital, and incidence of ventilator-associated pneumonia (SMD [95% CI]: -0.75 [-1.37 to -0.13]; -0.15 [CI: -0.25 to -0.04]; -1.22 [-2.44 to -0.01]; RR [95% CI]: 0.61 [0.42-0.89]; respectively). Based on our findings, intravenous selenium supplementation could not be sugge...Continue Reading

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Citations

Oct 8, 2019·British Journal of Hospital Medicine·I P Hargreaves, D Mantle
Jul 10, 2020·Archives of Physiology and Biochemistry·Fatemeh BourBourSaied Doaei
Feb 7, 2020·Nutrients·Elisabeth De WaeleHerbert Spapen
Apr 30, 2021·British Journal of Hospital Medicine·Sam RoweAnitra C Carr
May 14, 2021·The Journal of Nutrition·Philip T JamesAndrew M Prentice

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