A meta-analysis of studies investigating the effects of lead exposure on nerve conduction

Archives of Toxicology
Edward F KriegW Stephen Brightwell

Abstract

Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0 microg/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver.

References

Oct 1, 1978·Annals of Neurology·S J OhA G Diethelm
Jun 30, 1977·International Archives of Occupational and Environmental Health·R L Zielhuis
Oct 1, 1985·Scandinavian Journal of Work, Environment & Health·F He
Aug 1, 1985·Annals of Neurology·A J Windebank, P J Dyck
Oct 1, 1972·British Journal of Industrial Medicine·A M Seppäläinen, S Hernberg
Jul 1, 1974·Archives of Neurology·J A BoothbyL P Rowland
Apr 1, 1970·British Journal of Industrial Medicine·A Hopkins
Nov 9, 1968·British Medical Journal·B Livesley, C E Sissons
Apr 1, 1966·Journal of Neuropathology and Experimental Neurology·P M Fullerton
May 1, 1980·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C F Bolton
May 1, 1982·Seminars in Liver Disease·H L Bonkowsky, W Schady
Sep 25, 1997·Environmental Health Perspectives·M Loghman-Adham
Aug 20, 1955·Lancet·A M CAMPBELL
Nov 1, 1958·Annals of Physical Medicine·D PREISKEL
Dec 1, 1964·Journal of Neurology, Neurosurgery, and Psychiatry·J A SIMPSONJ F ADAMS
Oct 26, 2006·Kidney International·E B EkongV M Weaver

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Citations

Jul 24, 2008·Archives of Toxicology·J G Hengstler, H M Bolt
Oct 8, 2008·Archives of Toxicology·Azra Rabbani-ChadeganiShayesteh Mohammadian
Aug 17, 2011·International Journal of Environmental Research and Public Health·David C Bellinger
Apr 1, 2019·Occupational and Environmental Medicine·Cai-Guo YuJan A Staessen
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Mandakini S KshirsagarArun Patil
Jan 15, 2021·The International Journal of Neuroscience·Tülin AktürkHikmet Saçmacı
Apr 17, 2021·Journal of Occupational Medicine and Toxicology·Magdalena KoszewiczSlawomir Budrewicz
Jun 28, 2011·ACS Applied Materials & Interfaces·Yen-Fei Lee, Chih-Ching Huang

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