A meta-analysis of the association between body mass index and risk of vertebral fracture

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A D KazeJ M Paik

Abstract

We conducted a meta-analysis of prospective studies to assess the association between BMI and incident vertebral fracture. We found that as body mass index (BMI) increases, the risk of vertebral fracture decreases in men, but not in women, suggesting possible gender differences in the relationship of BMI with risk of vertebral fracture. Recent evidence suggests that the relationship between BMI and fracture risk may be site-specific. We conducted a systematic review and meta-analysis of prospective studies to investigate the association between BMI and risk of incident vertebral fracture. PubMed and Embase were searched for relevant articles published from inception through February 15, 2017. Extracted relative risks (RR) from the prospective studies were pooled using random-effects meta-analysis. Six studies were included, with a total of 105,129 participants followed for 3 to 19 years. The pooled RR (95% confidence interval [CI]) for vertebral fracture per each standard deviation increase in BMI was 0.94 (95% CI = 0.80-1.10) with significant heterogeneity (I 2 = 88.0%, p < 0.001). In subgroup analysis by gender, we found a significant inverse association between BMI and risk of vertebral fracture in men (RR = 0.85, 95% CI = 0...Continue Reading

References

May 1, 1989·American Journal of Epidemiology·L J MeltonB L Riggs
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 7, 1998·Spine·L J Melton
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y DuanC H Turner
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph Melton
Nov 2, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Alexandra PapaioannouJonathan D Adachi
Apr 22, 2006·Academic Radiology·L Joseph Melton, David F Kallmes
Jun 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A H HolmbergK Akesson
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Denise E BondsKaren L Margolis
Sep 29, 2006·Journal of the American Society of Nephrology : JASN·Thomas L NickolasElizabeth Shane
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Jan 1, 2008·JAMA : the Journal of the American Medical Association·Jane A CauleySteven R Cummings
Jul 7, 2009·Journal of Bone and Mineral Metabolism·Matteo PirroElmo Mannarino
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jul 6, 2010·Archives of Biochemistry and Biophysics·Ian R Reid
Sep 4, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carrie M NielsonUNKNOWN Osteoporotic Fractures in Men Study Research Group
Sep 15, 2010·Current Osteoporosis Reports·Blaine A Christiansen, Mary L Bouxsein
Jan 5, 2011·Bone·Miriam A BredellaKaren K Miller
Jun 17, 2011·Journal of Orthopaedic Surgery and Research·Jay J Cao
Aug 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L L LaslettG Jones
Oct 25, 2011·The American Journal of Medicine·Juliet E CompstonUNKNOWN Glow Investigators
Nov 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel Prieto-AlhambraAdolfo Díez-Pérez
Mar 13, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helena JohanssonDan Mellström
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Miriam A BredellaKaren K Miller
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S TanakaM Shiraki
Apr 6, 2013·The Journal of Clinical Endocrinology and Metabolism·Shuman YangTuan V Nguyen
Jun 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helena JohanssonM Carola Zillikens
Jul 23, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Juliet E CompstonUNKNOWN GLOW Investigators
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Lina AguirreReina Armamento-Villareal
May 24, 2015·Current Opinion in Rheumatology·Juliet Compston
Mar 8, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jason LacombeUNKNOWN Million Women Study collaborators
Jan 11, 2017·Current Opinion in Rheumatology·Jane A Cauley

❮ Previous
Next ❯

Citations

May 6, 2019·Aging Clinical and Experimental Research·Gabriela MihaiRaluca-Monica Pop
May 8, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Soto-SubiabreC Gómez-Vaquero
Jul 28, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Guowei LiJonathan D Adachi
Jan 23, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L VerasH Fonseca
Sep 22, 2018·Journal of Bone and Mineral Metabolism·Ippei KanazawaToshitsugu Sugimoto
Jan 8, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z ZhangX-H Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.