A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia

Psychiatric Genetics
Robert A Philibert

Abstract

Uncommon polymorphisms, particularly balanced uncommon polymorphisms, present a significant challenge to our understanding of their role in behavior. We have recently demonstrated that an uncommon candidate gene polymorphism for schizophrenia, known as HOPA12bp, is the defining polymorphism for a large X-chromosome haplotype in population disequilibrium and that it is associated with a positive syndrome of psychosis. Not all studies, however, have shown this effect. In this report, we reviewed prior studies and conducted meta-analysis of studies using probands of northern European extraction. We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association.

References

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Citations

Feb 7, 2012·Current Psychiatry Reports·Chris Murgatroyd, Dietmar Spengler
Sep 9, 2011·PloS One·Maria-Cristina KeightleyGraham J Lieschke
Aug 25, 2007·Pharmacogenomics·Robert A Philibert, Anup Madan
Aug 16, 2011·Seminars in Cell & Developmental Biology·Jason M SpaethThomas G Boyer
Mar 25, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Robert A PhilibertPamela Madden
Jul 6, 2007·Expert Review of Neurotherapeutics·Robert A Philibert, Howard K Gershenfeld
Feb 15, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertDonald W Black
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patrik Roser, Wolfram Kawohl
Sep 30, 2010·Immunopharmacology and Immunotoxicology·Simona Lucia BavaroDarja Kanduc

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