A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer's disease.

Scientific Reports
Ayuni YussofSulie L Chang

Abstract

The diversity of bacterial species in the oral cavity makes it a key site for research. The close proximity of the oral cavity to the brain and the blood brain barrier enhances the interest to study this site. Changes in the oral microbiome are linked to multiple systemic diseases. Alcohol is shown to cause a shift in the microbiome composition. This change, particularly in the oral cavity, may lead to neurological diseases. Alzheimer's disease (AD) is a common neurodegenerative disorder that may cause irreversible memory loss. This study uses the meta-analysis method to establish the link between binge drinking, the oral microbiome and AD. The QIAGEN Ingenuity Pathway Analysis (IPA) shows that high levels of ethanol in binge drinkers cause a shift in the microbiome that leads to the development of AD through the activation of eIF2, regulation of eIF4 and p70S6K signaling, and mTOR signaling pathways. The pathways associated with both binge drinkers and AD are also analyzed. This study provides a foundation that shows how binge drinking and the oral microbiome dysbiosis lead to permeability changes in the blood brain barrier (BBB), which may eventually result in the pathogenesis of AD.

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Citations

Feb 16, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Fulvio LauretaniMarcello Maggio
Oct 26, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sierra SimpsonOlivier George

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Datasets Mentioned

BETA
SRP133146
SRP133149
28
PRJNA434300
PRJNA190012
PRJNA
94069
GSE3846

Software Mentioned

QIAGEN
Core Expression Analysis
IPA
Build a Pathway setting Activity Predictor ( MAP )
PRISMA
Ingenuity Pathway Analysis ( IPA )
Core Analysis in IPA

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