A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting

BMC Cardiovascular Disorders
Tejas P SinghJonathan Golledge

Abstract

The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk individuals. The aim of this meta-analysis was to assess the efficacy of allopurinol treatment in reducing the incidence of MI. MEDLINE, Scopus, Web of Science, and Cochrane Library databases were searched for randomised controlled trials examining the efficacy of allopurinol in reducing the incidence of MI. The quality of study methodology was assessed by two independent reviewers using the Cochrane Collaboration's tool for assessing risk of bias. This meta-analysis was conducted using a fixed-effects model, and heterogeneity was assessed with the I2 index. One thousand one hundred twenty-three citations were screened and only six studies satisfied the inclusion criterion. Published between 1988 and 1995, all studies examined the cardioprotective efficacy of allopurinol in the setting of coronary artery bypass graft (CABG). From a total pooled sample size of 229, MI was reported in 2 (1.77%) allopurinol and 14 (12.07%) control patients. A fixed-effects meta-analysis (I2 = 0%) identified a statistically significant reduced ...Continue Reading

References

Jun 1, 1978·Journal of the American Geriatrics Society·I SaitoE Kato
Nov 1, 1977·The Journal of Clinical Investigation·M H GinsbergD J McCarty
Jul 1, 1991·The Annals of Thoracic Surgery·M A Rashid, G William-Olsson
Aug 1, 1995·Free Radical Biology & Medicine·J A GimpelJ F Hitchcock
Jan 1, 1995·Journal of Cardiovascular Pharmacology·P CastelliE Riva
Dec 1, 1994·Journal of Cardiovascular Pharmacology·A MüggeP R Lichtlen
Feb 1, 1994·British Heart Journal·D P TaggartJ E Wright
Dec 2, 1999·Atherosclerosis·F J NietoR G Cutler
May 9, 2002·American Journal of Physiology. Renal Physiology·Marilda MazzaliRichard J Johnson
Sep 27, 2002·QJM : Monthly Journal of the Association of Physicians·W S Waring
Jan 29, 2003·Circulation·Sashi GuthikondaWilliam G Haynes
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 24, 2009·Cardiovascular Psychiatry and Neurology·Peter HigginsMatthew Walters
Jul 12, 2011·Diabetes Research and Clinical Practice·Karl E MingesJonathan E Shaw
Dec 1, 2006·British Journal of Clinical Pharmacology·Jesse Dawson, Matthew Walters
Jul 18, 2012·Heart·Allan Struthers, Fiona Shearer
Jan 8, 2014·Annals of the Rheumatic Diseases·L Grimaldi-BensoudaUNKNOWN PGRx MI Group
Jan 7, 2015·Heart·Francisco J de AbajoLuis A García-Rodríguez
Jan 18, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marian GoicoecheaJose Luño
Nov 22, 2015·The American Journal of Medicine·Kasper Søltoft LarsenJesper Hallas
Feb 13, 2016·Hypertension·Rachael L MacIsaacJesse Dawson
Sep 23, 2016·Arthritis Research & Therapy·Jasvinder A Singh, Shaohua Yu
Oct 21, 2016·Journal of Cardiovascular Pharmacology·Ahmad SeparhamHossein Babaei

❮ Previous
Next ❯

Citations

Dec 17, 2019·Current Opinion in Rheumatology·Abhishek Abhishek
Feb 25, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mallory T MouradjianSandeep Devabhakthuni

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Excel
Scopus
RevMan
Cochrane

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.