A meta-analysis of the efficacy of second-generation antipsychotics

Archives of General Psychiatry
John M DavisIra D Glick


Consensus panel recommendations regarding choice of an antipsychotic agent for schizophrenia differ markedly, but most consider second-generation antipsychotics (SGAs) as a homogeneous group. It has been suggested that SGAs seem falsely more efficacious than first-generation antipsychotics (FGAs) as a result of reduced efficacy due to use of a high-dose comparator, haloperidol. We performed (1) a meta-analysis of randomized efficacy trials comparing SGAs and FGAs, (2) comparisons between SGAs, (3) a dose-response analysis of FGAs and SGAs, and (4) an analysis of the effect on efficacy of an overly high dose of an FGA comparator. Literature search of clinical trials between January 1953 and May 2002 of patients with schizophrenia from electronic databases, reference lists, posters, the Food and Drug Administration, and other unpublished data. We included 124 randomized controlled trials with efficacy data on 10 SGAs vs FGAs and 18 studies of comparisons between SGAs. Two of us independently extracted the sample sizes, means, and standard deviation of the efficacy data. Using the Hedges-Olkin algorithm, the effect sizes of clozapine, amisulpride, risperidone, and olanzapine were 0.49, 0.29, 0.25, and 0.21 greater than those of FG...Continue Reading

Associated Clinical Trials

Jul 13, 2006·David C. Henderson, MD, David C. Henderson, MD


Apr 3, 2014·Annals of General Psychiatry·Joseph PeuskensAndreas Schreiner
Oct 2, 2012·Annual Review of Medicine·Herbert Y Meltzer
Sep 28, 2010·Annual Review of Pharmacology and Toxicology·Hisham M Ibrahim, Carol A Tamminga
Oct 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Del D MillerUNKNOWN Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
May 28, 2010·The British Journal of Psychiatry. Supplement·Maxine X PatelAnthony S David
Jun 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Nicolas A CrossleyPaddy Power
Apr 29, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Peter LeppingRob Poole
Mar 3, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Peter McKenna
Jun 22, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David M GardnerPaul Waraich
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Gerard Marek, Kalpana Merchant
Jun 1, 2006·Clinical Practice and Epidemiology in Mental Health : CP & EMH·L HanssensJ Peuskens
Jun 10, 2006·BMJ : British Medical Journal·Rohan Ganguli, Martin Strassnig
Aug 15, 2006·Schizophrenia Bulletin·Stefan LeuchtJohn M Davis
Aug 19, 2006·Schizophrenia Bulletin·Volker RoderHans D Brenner
Jun 15, 2007·Schizophrenia Bulletin·Carol A Tamminga, John M Davis
Jul 20, 2007·Schizophrenia Bulletin·R A RosenheckMichael Sernyak
Sep 5, 2007·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Eric AcquavivaBruno Falissard
Jan 18, 2008·Schizophrenia Bulletin·John M Kane, Stefan Leucht
Feb 5, 2008·Schizophrenia Bulletin·T Scott Stroup, John R Geddes
Mar 4, 2008·Implementation Science : IS·Paul R FalzerD Melissa Garman
Mar 13, 2008·Schizophrenia Bulletin·John M Davis, Stefan Leucht
Mar 25, 2008·Therapeutics and Clinical Risk Management·Philippe NussCédric Tessier
Apr 29, 2008·BMC Psychiatry·Erik Johnsen, Hugo A Jørgensen
Jul 29, 2008·Schizophrenia Bulletin·C LeuchtS Leucht
Jul 31, 2008·Journal of Psychiatric Practice·Caroline Bonham, Christopher Abbott
Aug 30, 2008·Neuropsychiatric Disease and Treatment·A Carlo Altamura, Jose M Goikolea
Sep 2, 2008·Journal of Child and Adolescent Psychopharmacology·Sanjiv KumraJohn M Kane
Jan 15, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Richard A HansenBradley N Gaynes
Apr 2, 2009·Psychopharmacology·Atheir I AbbasBryan L Roth
Jun 27, 2009·Neuropsychiatric Disease and Treatment·Ann M Mortimer
Oct 21, 2009·PLoS Medicine·Mari Jair de JesusGraham Thornicroft
Nov 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruce J KinonJohn M Kane
Jan 6, 2010·Indian Journal of Psychiatry·R K SolankiDeepti Munshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here