A meta-analysis of the NAT1 and NAT2 polymorphisms and prostate cancer: a huge review.

Medical Oncology
Chunming GongZengnan Mo

Abstract

Studies revealing conflicting results on the role of NAT1 or NAT2 phenotypes on prostate cancer risk led us to perform a meta-analysis to investigate the association of these polymorphisms and prostate cancer risk. The meta-analysis included six studies with NAT1 genotyping (610 prostate cancer cases and 713 controls), and 10 studies with NAT2 genotyping (1,253 cases and 1,722 controls). The fixed effects odds ratio was 0.96 [95% confidence interval (95% CI): 0.75, 1.21; I(2) = 32.9%, P for heterogeneity = 0.189] for the NAT1 genotype, and the random effects odds ratio was 1.10 (95% CI: 0.87, 1.39; I(2) = 49.1%, P for heterogeneity = 0.039) for the NAT2 genotype. For NAT2 polymorphism, a statistically significant association between NAT2 polymorphism and prostate cancer appeared in Asians, but not in Caucasians. In conclusion, the NAT1 or NAT2 phenotypes detoxify carcinogens and their reactive intermediates are unlikely to be the cause of PCa development.

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M BlumU A Meyer
Jun 28, 1991·Biochemical and Biophysical Research Communications·T Ebisawa, T Deguchi
Aug 8, 1991·Biochemical Pharmacology·D Hickman, E Sim
Jun 1, 1991·Trends in Pharmacological Sciences·E Sime, D Hickman
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K P VatsisW W Weber
Apr 1, 1995·Pharmacogenetics·N Caporaso, A Goldstein
Apr 9, 1999·International Journal of Epidemiology·M BlettnerC Friedenreich
Jun 10, 2000·The British Journal of Dermatology·G A WestphalA Schnuch
Jun 22, 2000·Pharmacogenetics·D W HeinE Sim
Mar 10, 2001·Trends in Pharmacological Sciences·A UptonE Sim
Dec 14, 2001·Cancer Letters·Terence Lawson, Carol Kolar
Mar 8, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi HamasakiTetsuro Matsumoto
May 9, 2003·The Urologic Clinics of North America·Peter BoyleGraham G Giles
Nov 6, 2003·The Prostate·Steve EdwardsUNKNOWN International ACTANE Consortium
Mar 17, 2004·La Revue du praticien·Xavier RébillardArnauld Villers
Apr 8, 2004·Current Opinion in Urology·Eric A Klein, Ian M Thompson
Oct 14, 2004·Clinical Prostate Cancer·Yoshihisa KinoshitaGabriel P Haas
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 3, 2005·Prostate Cancer and Prostatic Diseases·P M RovitoG P Haas
Jan 10, 2006·Methods in Enzymology·Kim DalhoffHenrik Enghusen Poulsen
Apr 3, 2007·Nature Genetics·Meredith YeagerGilles Thomas
Nov 21, 2007·Prostate Cancer and Prostatic Diseases·S HookerR A Kittles
Feb 12, 2008·Nature Genetics·Gilles ThomasStephen J Chanock
Feb 12, 2008·Nature Genetics·Rosalind A EelesDouglas F Easton

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Citations

May 13, 2014·Medical Oncology·Marta VilčkováMonika Kmeťová Sivoňová
Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liang ZhangYi Zhu
Jun 15, 2014·Reproductive Biomedicine Online·Sergey L YaroshAlexey V Polonikov
Feb 2, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ZhangChunhui Ouyang
Mar 19, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hassan R Dhaini, Loulou Kobeissi
May 17, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stephen C Mitchell
Jun 23, 2012·Molecular Biology Reports·Xian-Lu ZhuoYing-Hui Tan
Dec 12, 2012·Experimental and Therapeutic Medicine·Wenlei ZhuoZhengtang Chen

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