A meta-analysis of the use of rifaximin to prevent travellers' diarrhoea

Journal of Travel Medicine
Qin Xiang NgHwei Wuen Chan

Abstract

Travellers' diarrhoea affects tens of millions of people travelling to less developed countries or regions annually. There are positive reports of the use of rifaximin, a non-absorbed, gut-selective antibiotic to prevent travellers' diarrhoea. This study will critically review and analyse clinical trials on the subject. Using the keywords [diarrhoea OR diarrhoea OR travel*] AND [rifaximin OR xifaxan OR xifaxanta OR normix OR rifagut], a preliminary search on the PubMed and Ovid databases yielded 411 papers published in English between 1 January 1988 and 1 July 2016. Of these, there were only five relevant clinical trials. The clinical trials were double-blind, placebo-controlled, randomized trials with a total of 879 subjects. The meta-analysis found significant reduction in risk of travellers' diarrhoea with rifaximin use compared to placebo (pooled RR 0.478, 95% CI: 0.375-0.610, and P  < 0.001). For the entire travel and follow-up period, the risk of developing travellers' diarrhoea was significantly greater in individuals receiving the placebo than those receiving rifaximin (daily doses of 400-600 mg). Overall, rifaximin offered significant protection rates of 48-72%, with lower protection rates for Asian than Latin American...Continue Reading

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Citations

Sep 22, 2020·Future Microbiology·Lyudmila BoyanovaIvan Mitov
Nov 30, 2019·Military Medicine·Tahaniyat LalaniDavid R Tribble
Feb 19, 2021·Deutsches Ärzteblatt International·Sebastian WendtChristoph Lübbert
Sep 24, 2021·Deutsche medizinische Wochenschrift·Melanie SasseChristoph Lübbert

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