Abstract
Studies on polymorphism of X-ray repair cross-complementing group 1 (XRCC1), group 3 (XRCC3), and colorectal cancer risk are inconclusive. The purpose of this study is to evaluate the role of XRCC1 R399Q, R194W, and XRCC3 T241M genotypes in colorectal cancer susceptibility. We performed a meta-analysis on all available studies that provided 3,514/4,686 cases/controls for R399Q, 2,767/3,907 cases/controls for R194W and 3,183/3,926 cases/controls for T241M. Overall, no apparent effects of 194 W allele compared to 194R on colorectal cancer risk were found in all subjects and subgroups (Asians and Caucasians). Insignificant effects were also found under other genetic contrasts (homologous contrast, dominant model, and recessive model). The same pattern of results was produced in T241M polymorphism. The 399Q allele compared to 399R showed no significant association with colorectal cancer risk in all subjects and subgroups. However, protective effects of 399QQ genotype were observed under recessive model (QQ/QR + RR) [P = 0.02, OR = 0.84, 95% CI (0.72, 0.97)] and homozygote contrast (QQ/RR) [P = 0.01, OR = 0.81; 95% CI (0.69, 0.95)] in all subjects. Results suggested that 399Q allele might act as a recessive allele in its association...Continue Reading
References
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·R S TebbsL H Thompson
Jul 31, 1993·BMJ : British Medical Journal·H J Thomas
Jan 26, 1996·International Journal of Cancer. Journal International Du Cancer·P VineisP Strickland
Nov 15, 1996·Nucleic Acids Research·K W CaldecottS Shall
Sep 20, 1997·The Journal of Biological Chemistry·E CappelliG Frosina
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Jun 20, 1998·Molecular and Cellular Biology·M MassonG de Murcia
Sep 12, 1998·The Journal of Biological Chemistry·R J Sanderson, D W Mosbaugh
Sep 7, 2000·Cancer Letters·S Z Abdel-RahmanB Levin
Apr 17, 2001·International Journal of Cancer. Journal International Du Cancer·G MatulloP Vineis
Nov 21, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G L David-Beabes, S J London
Apr 19, 2002·Carcinogenesis·Sai-Mei HouKari Hemminki
May 9, 2002·Mutation Research·Caroline L ReltonE Janet Tawn
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Oct 24, 2002·Blood·Claire SeedhouseEmma Das-Gupta
Mar 6, 2003·Mechanisms of Ageing and Development·Warren LadigesAlasdair MacAuley
Mar 6, 2003·Cancer Letters·R Rita MisraDemetrius Albanes
Jul 17, 2003·British Journal of Cancer·R MortD W Melton
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Apr 27, 2004·Nucleic Acids Research·Jinshui FanDavid M Wilson
Feb 1, 2005·BMC Cancer·Chih-Ching YehLing-Ling Hsieh
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mariana C SternRobert W Haile
Apr 1, 2005·International Journal of Cancer. Journal International Du Cancer·Yun-Chul HongHo Kim
Jul 30, 2005·Seminars in Respiratory and Critical Care Medicine·Geoffrey LiuDavid C Christiani
Nov 8, 2005·Cancer Genetics and Cytogenetics·Ming-Juan JinKai-Yan Yao
Mar 18, 2006·BMC Cancer·Camilla Furu SkjelbredElin H Kure
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Victor MorenoFederico Canzian
Feb 7, 2007·Cancer Research·Sonja I BerndtRichard B Hayes
Apr 10, 2007·Mutation Research·Alessio NaccaratiPavel Vodicka
Nov 17, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mariana C SternMimi C Yu
Citations
Nov 26, 2010·Molecular Biology Reports·Renata KrupaJanusz Blasiak
Sep 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Wei-Dong ShenPeng-Fei Liu
Sep 29, 2012·Journal of the National Cancer Institute·Evropi TheodoratouJulian Little
Feb 2, 2012·Mutagenesis·Ian P M TomlinsonMalcolm G Dunlop
Jun 6, 2014·PloS One·Lijun JingBrian Z Ring
Apr 15, 2011·Journal of Biomedicine & Biotechnology·Lucia MiglioreFabio Coppedè
May 27, 2011·Cancer Epidemiology·Andrea GsurMichael Micksche
Mar 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·ZhiZhen Wang, Wencheng Zhang
Aug 20, 2010·Journal of Applied Genetics·K JelonekP Widlak
Oct 29, 2010·Journal of Cancer Research and Clinical Oncology·Bo ChenXiao-Ting Wu
Jun 16, 2010·Medical Oncology·Fang FangLong Yu
Jul 3, 2015·Oncology Letters·Jinghua FanLimin Zhao
Apr 27, 2013·Mutation Research·Karolina PrzybylowskaIreneusz Majsterek
Jun 27, 2012·Mutation Research·Valeria SimonelliEugenia Dogliotti
Dec 14, 2011·Mutation Research·Valeria SimonelliEugenia Dogliotti
Aug 26, 2011·Mutation Research·Fulvio RicceriPaolo Vineis
Feb 1, 2011·Mutation Research·M BettiI Dianzani
Apr 11, 2012·The Journal of Obstetrics and Gynaecology Research·Hanna Romanowicz-MakowskaStanisław Sporny
May 17, 2011·Cytokine·Bo ChenXiao-Ting Wu
Apr 9, 2013·Gene·Xiao-Feng HeDao-Lin Xie
Jan 7, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Tze-Pheng LauKek-Heng Chua
Dec 29, 2012·Molecular Biology Reports·Li LiuZhining Fan
Jul 10, 2019·Nutrients·Bobbi B LaingLynnette R Ferguson
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kirati PoomphakwaenSurapon Wiangnon
May 24, 2011·Molecular Biology Reports·Bo ChenXiao-Ting Wu
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bin ZhangYan-Bin Jia
Apr 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M SuenagaH-J Lenz