PMID: 9427902Jan 15, 1998Paper

A meta-analytic review of the preventive treatment of recurrences of febrile seizures

The Journal of Pediatrics
H RantalaM Uhari

Abstract

To assess the efficacy of various medications in the prevention of recurrent febrile seizures. A meta-analysis of all published randomized, placebo-controlled trials of the preventive treatment of febrile seizures published in English; 45 articles were found, but only 9 trials were randomized and placebo-controlled--4 using phenobarbital; 3, diazepam; 1, pyridoxine; and 1, phenytoin. In one of the phenobarbital trials, valproate was also compared with placebo. The risk of recurrences was significantly lower in children receiving continuous phenobarbital therapy than placebo (odds ratio 0.54, 95% confidence intervals 0.33 to 0.90, p = 0.017). The odds ratio for recurrences in the valproate group was 0.09, 95% CI 0.01 to 0.78, p = 0.011. No difference in the risk was found for recurrences between children receiving intermittent diazepam and placebo (odds ratio 0.81, 95% CI 0.54 to 1.22, p = 0.31). The risk for recurrences in children receiving pyridoxine or phenytoin did not differ from the risk among children receiving placebo. Four children would have to be treated with valproate (95% CI 2 to 11) or eight children would have to be treated with phenobarbital (95% CI 5 to 27), continuously, to prevent one febrile seizure. Because...Continue Reading

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Citations

Jul 13, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Efterpi PavlidouChristos Panteliadis
Dec 24, 2008·World Journal of Pediatrics : WJP·Miguel Glatstein, Dennis Scolnik
Jan 22, 2000·Epilepsia·F U Knudsen
Apr 8, 2011·Epilepsia·Catherine Chiron, Olivier Dulac
Jul 23, 2004·Archives of Disease in Childhood·C Waruiru, R Appleton
Nov 10, 2001·BMJ : British Medical Journal·M Offringa, V A Moyer
Sep 29, 2001·The Western Journal of Medicine·M Offringa, V A Moyer
Apr 20, 2001·Paediatric Drugs·G O Akpede, G I Akenzua
Apr 13, 2006·Paediatric Drugs·Renzo Guerrini
Aug 12, 2014·Indian Journal of Pediatrics·Rekha Mittal
Feb 21, 2013·The Journal of Pharmacology and Experimental Therapeutics·John C OakleyWilliam A Catterall
Sep 5, 2007·European Journal of Pediatrics·Arne Fetveit
Jul 24, 2013·Evidence-based Child Health : a Cochrane Review Journal·Martin Offringa, Richard Newton
Jun 11, 2010·Emergency Medicine Australasia : EMA·Katharine Gallop
May 23, 2000·Annals of Medicine·H RantalaM Uhari
Jan 28, 2003·Annals of Emergency Medicine·Craig R WardenMarianne Gausche-Hill
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Apr 23, 2005·The Cochrane Database of Systematic Reviews·L N Ranganathan, S Ramaratnam
Jun 17, 2021·The Cochrane Database of Systematic Reviews·Martin OffringaKaterina Vraka

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