A Meta-Analytic Review of the Value of miRNA for Multiple Sclerosis Diagnosis

Frontiers in Neurology
Zongpu ZhouYing Feng

Abstract

Backgrounds and Purpose: Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system. The etiology of MS is unclear, disease diagnosis mainly based on symptoms, and lacks effective laboratory test index. Circulating microRNAs (miRNAs) as sensitive biomarkers have been widely studied, the expression levels of certain miRNAs are dynamically changed in MS patients. This meta-analysis aims to assess the overall diagnostic accuracy of circulating miRNAs for MS. Methods: We searched PubMed, EMBASE, Cochrane Library, CNKI databases as of July 20, 2019. QUADAS was used to assess the quality of included studies. All studies were processed by Stata 15.0 software. Eleven articles with 600 patients with MS and 389 controls were included. Results: The sensitivity and specificity, PLR, NLR, and DOR of the overall studies were 0.81 (95% CI 0.77-0.84), 0.75 (95% CI 0.68-0.81), 3.3 (95% CI 2.5-4.3), 0.25 (95% CI 0.20-0.32), 13 (95% CI: 8-20), and 0.85 (95% CI 0.82-0.88). Subgroup analysis indicated that miRNA assay had higher diagnostic accuracy for relapsing-remitting MS (RRMS) when compared with other MS subtypes. Conclusion: Our study performed a meta-analysis to generate an estimate...Continue Reading

References

Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jun 22, 2007·The New England Journal of Medicine·Christel RenouxUNKNOWN Adult Neurology Departments KIDMUS Study Group
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Jan 16, 2009·Nature Reviews. Molecular Cell Biology·Peter Brodersen, Olivier Voinnet
Nov 26, 2009·Autoimmunity Reviews·Ron Milo, Esther Kahana
Oct 30, 2010·Nature Reviews. Drug Discovery·Volker BrinkmannPascale Burtin
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 14, 2011·Clinical Chemistry·Jennifer S McDonaldAlicia Algeciras-Schimnich
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Dec 30, 2011·Journal of Autoimmunity·Shashi AmurPadmaja Mummaneni
Apr 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marcin P MyckoKrzysztof W Selmaj
Mar 16, 2013·Annals of Neurology·Roopali GandhiHoward L Weiner
Jun 19, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Helle Bach SøndergaardFinn Sellebjerg
Jul 10, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Andreas KellerKlemens Ruprecht
Jan 1, 2012·Multiple Sclerosis and Related Disorders·Markus KippSandra Amor
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Roopali Gandhi
May 8, 2015·Journal of Translational Medicine·Roberta MancusoMario Clerici
Mar 5, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li-hua XuShao-yan Hu
May 5, 2016·Neurology. Neuroimmunology and Neuroinflammation·Petra BergmanMaja Jagodic
Jun 2, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Julia VistbakkaSanna Hagman
Feb 18, 2017·Nature Reviews. Drug Discovery·Rajesha Rupaimoole, Frank J Slack
Apr 8, 2017·Journal of Neuroimmunology·Igor SelmajKrzysztof W Selmaj
Apr 16, 2017·Annals of Neurology·Igor SelmajMarcin P Mycko
Jul 8, 2017·Nature Reviews. Drug Discovery·Jason R PlemelV Wee Yong
Sep 19, 2017·Advances in Experimental Medicine and Biology·Claire E McCoy
Nov 1, 2017·Scientific Reports·Saeideh EbrahimkhaniMichael E Buckland
May 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sanam DolatiMehdi Yousefi
Sep 4, 2018·Neurology. Neuroimmunology and Neuroinflammation·Keren RegevRoopali Gandhi
Nov 23, 2018·International Journal of Molecular Sciences·Nicoletta NuzzielloMaria Liguori

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

QUADAS

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