A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression

Kidney International
Guanshi ZhangKumar Sharma

Abstract

In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine) were identified as early risk factors for chronic kidney disease, and metabolites with genomewide association study analysis identified associations of urinary metabolites (i.e., lysine and NG-monomethyl-l-arginine) with single-nucleotide polymorphisms of SLC7A9.

References

Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Caroline S FoxDaniel Levy
May 17, 2011·Nature Genetics·Karsten SuhreMatthias Nauck
Mar 13, 2012·Nature Medicine·Yuanmeng JinJohn Cijiang He
Aug 21, 2013·Journal of the American Society of Nephrology : JASN·Kumar SharmaRobert K Naviaux
May 13, 2014·Nature Genetics·So-Youn ShinNicole Soranzo
Dec 4, 2015·Science Translational Medicine·Wenjun JuUNKNOWN ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium
Oct 26, 2016·JCI Insight·Rintaro SaitoKumar Sharma
Dec 17, 2016·Metabolomics : Official Journal of the Metabolomic Society·Markus RotterRui Wang-Sattler

❮ Previous
Next ❯

Citations

Nov 25, 2018·Plant, Cell & Environment·Somayanda M ImpaS V Krishna Jagadish
May 7, 2019·Frontiers in Genetics·Siriluck PonsuksiliKlaus Wimmers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity : Journal of the International Association for the Study of Obesity
B XiJ Mi
European Urology
Orestis A PanagiotouKonstantinos K Tsilidis
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Isabel MendonçaJosé Jorge Araújo
© 2022 Meta ULC. All rights reserved