A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases

Fitoterapia
François ChassagneGuillaume Marti

Abstract

Liver cancer is a major health burden in Southeast Asia, and most patients turn towards the use of medicinal plants to alleviate their symptoms. The aim of this work was to apply to Southeast Asian plants traditionally used to treat liver disorders, a successive ranking strategy based on a comprehensive review of the literature and metabolomic data in order to relate ethnopharmacological relevance to chemical entities of interest. We analyzed 45 publications resulting in a list of 378 plant species, and our point system based on the frequency of citation in the literature allowed the selection of 10 top ranked species for further collection and extraction. Extracts of these plants were tested for their in vitro anti-proliferative activities on HepG2 cells. Ethanolic extracts of Andrographis paniculata, Oroxylum indicum, Orthosiphon aristatus and Willughbeia edulis showed the highest anti-proliferative effects (IC50 = 195.9, 64.1, 71.3 and 66.7 μg/ml, respectively). A metabolomic ranking model was performed to annotate compounds responsible for the anti-proliferative properties of A. paniculata (andrographolactone and dehydroandrographolide), O. indicum (baicalein, chrysin, oroxylin A and scutellarein), O. aristatus (5-desmethyl...Continue Reading

Citations

Jul 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin GanWenqing Zhang
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiobouaphong PhakeovilayGuillaume Marti
Jun 15, 2019·Journal of Ethnobiology and Ethnomedicine·Jean Marc DubostGeneviève Bourdy
Aug 21, 2020·Journal of Ethnopharmacology·Pedro G Vásquez-OcmínAlexandre Maciuk
Jan 14, 2020·Journal of Photochemistry and Photobiology. B, Biology·Zhenjiang LiArunachalam Chinnathambi
Dec 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nik Nur Hakimah Nik SallehSuat Cheng Tan
Jan 2, 2021·Metabolites·Seham S El-HawaryElham Amin
Apr 17, 2021·Cancer Cell International·Marjan TalebiSaeed Samarghandian
May 25, 2021·Fitoterapia·André Néhémie BitomboChristian G Bochet

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