A metabolomic study of fipronil for the anxiety-like behavior in zebrafish larvae at environmentally relevant levels

Environmental Pollution
Cui WangMeirong Zhao

Abstract

Field residue of fipronil can interfere with the physiological characters of the domesticated fish; thus, lethal dose test and the general biomarker cannot delineate the low-level situation. Manipulating by video track, we observed an anxiety-like behavior including high speed and abnormal photoperiod accommodation after exposure to fipronil at environmental typical dose in zebrafish larvae. Examining the unbiased metabolomic profiles, we found perturbation in several metabolic pathways, including the increased contents of fatty acids and glycerol and the decreased levels of the glycine, serine, and branched amino acid. We presumed that observed enhanced fatty acid utility was in response to increase energy demands caused by anxiety like behavior. Additionally, the body burden of neurotransmitter such as glycine and L-glutamate may concurrently stimulate the swimming behavior. The insight of this study showed that integral perturbation such as metabolism helps us to further understand the risk to aquatic fish at the environmentally relevant levels.

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Citations

Oct 11, 2016·Environmental Toxicology and Pharmacology·Lu YanCui Wang
Nov 11, 2017·Environmental Science and Pollution Research International·Lennard PisaJean-Marc Bonmatin
Jun 14, 2019·Archives of Environmental Contamination and Toxicology·Fabiele da Costa ChauletLeonardo José Gil Barcellos
Feb 28, 2021·Environmental Science and Pollution Research International·Adam Bownik, Aleksandra Szabelak
Oct 30, 2018·Journal of Agricultural and Food Chemistry·Song FangFanyu Kong
Sep 22, 2021·Environmental Science and Pollution Research International·Natália Prudêncio VianaMarisa Narciso Fernandes

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