A metabolomics approach to the identification of biomarkers of sugar-sweetened beverage intake

The American Journal of Clinical Nutrition
Helena GibbonsL Brennan

Abstract

The association between sugar-sweetened beverages (SSBs) and health risks remains controversial. To clarify proposed links, reliable and accurate dietary assessment methods of food intakes are essential. The aim of this present work was to use a metabolomics approach to identify a panel of urinary biomarkers indicative of SSB consumption from a national food consumption survey and subsequently validate this panel in an acute intervention study. Heat map analysis was performed to identify correlations between ¹H nuclear magnetic resonance (NMR) spectral regions and SSB intakes in participants of the National Adult Nutrition Survey (n = 565). Metabolites were identified and receiver operating characteristic (ROC) analysis was performed to assess sensitivity and specificity of biomarkers. The panel of biomarkers was validated in an acute study (n = 10). A fasting first-void urine sample and postprandial samples (2, 4, 6 h) were collected after SSB consumption. After NMR spectroscopic profiling of the urine samples, multivariate data analysis was applied. A panel of 4 biomarkers-formate, citrulline, taurine, and isocitrate-were identified as markers of SSB intake. This panel of biomarkers had an area under the curve of 0.8 for ROC ...Continue Reading

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Citations

Oct 17, 2015·Expert Review of Proteomics·Jianqiang Wu, Youhe Gao
Aug 31, 2016·Progress in Nuclear Magnetic Resonance Spectroscopy·John P M van Duynhoven, Doris M Jacobs
May 26, 2016·The Proceedings of the Nutrition Society·Helena Gibbons, Lorraine Brennan
Oct 27, 2016·Journal of Proteome Research·Gözde GürdenizLars Ove Dragsted
Jan 17, 2017·The Proceedings of the Nutrition Society·A O'Gorman, L Brennan
Feb 2, 2017·Journal of Proteome Research·Aoife O'GormanLorraine Brennan
Jul 18, 2015·Nutrients·Natasha Tasevska
Dec 20, 2017·Genes & Nutrition·Qian GaoLars O Dragsted
Feb 16, 2019·The Proceedings of the Nutrition Society·Cassandra CollinsLorraine Brennan
Mar 26, 2019·Annual Review of Food Science and Technology·Diana González-Peña, Lorraine Brennan
Apr 5, 2019·Statistical Methods in Medical Research·Isobel Claire GormleyLorraine Brennan
Apr 27, 2019·The Proceedings of the Nutrition Society·Alison M Gallagher, Caomhán Logue
May 3, 2019·Metabolomics : Official Journal of the Metabolomic Society·A J LloydJ Draper
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Apr 4, 2020·Molecular Nutrition & Food Research·Aoife E McNamaraLorraine Brennan
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Apr 27, 2019·Frontiers in Nutrition·Abdellah Tebani, Soumeya Bekri
Dec 7, 2018·Nutrients·Pedapati S C Sri HarshaLorraine Brennan
May 27, 2020·The Proceedings of the Nutrition Society·Aoife E McNamara, Lorraine Brennan
Dec 8, 2020·Human Molecular Genetics·Beatriz Calvo-SerraMariona Bustamante
Feb 2, 2021·Frontiers in Nutrition·Aoife E McNamaraLorraine Brennan
May 21, 2021·Advances in Nutrition·Talha RafiqPhilip Britz-McKibbin

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