A metabonomic analysis reveals novel regulatory mechanism of Huangqi injection on leucopenia mice

Immunopharmacology and Immunotoxicology
Tingli QuXue-Mei Qin

Abstract

Huangqi injection (HQI), extracted from Astragali Radix, which has capability on treating the leucopenia. However, the potential metabolic mechanism is poorly understood. To investigate the effect of HQI on cyclophosphamide (Cy)-induced leucopenia in mice, the nuclear magnetic resonance (NMR)-based metabolomic profiling technique coupled with multivariate statistical analysis was applied. NMR analysis was used to identify the various compounds of HQI, and high-performance liquid chromatography was applied to determine the contents of major compounds. A experimental mice model of leucopenia induced by Cy and NMR-based metabolomic approach was used to evaluate the pharmacological effect of HQI and to investigate its probable acting mechanism on leucopenia. HQI increased body weight and elevated the white blood cell (WBC), monocytes (MO), neutrophils (NE), and lymphocyte (LY) levels of Cy-treated mice. In addition, the levels of most perturbed endogenous metabolites could be reversed after HQI treatment. Correlations between WBC, MO, NE, LY, and altered metabolite profiles in spleen were greater than that in serum, and the correlation in MO was more evident than those for WBC, NE, and LY. HQI showed obvious efficacy on the mice mo...Continue Reading

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Citations

Apr 16, 2019·Rejuvenation Research·Si-Jun ZhaoXue-Mei Qin
Jul 1, 2018·Natural Products and Bioprospecting·Qi ZhaoFei Li
Apr 25, 2019·BMC Complementary and Alternative Medicine·Jin-Yong ZhouShen-Lin Liu
Sep 4, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Junqiu LiuGuoyin Kai

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