A metabotropic glutamate receptor family gene in Dictyostelium discoideum

The Journal of Biological Chemistry
Hideo TaniuraYukio Yoneda

Abstract

Metabotropic glutamate receptors (mGluRs) are a class of G-protein-coupled receptors that possess a seven transmembrane region involved in the modulation of excitatory synaptic transmission in the nervous system. mGluR orthologs have been identified in Drosophila, Caenorhabditis elegans, and higher organisms. Drosophila possesses two mGluR genes, DmGluRA and DmXR. We screened the Dictyostelium genome data base using the ligand binding domain of rat mGluR1 as bait, and identified a new receptor, DdmGluPR, belonging to the mGluR family. Similar to Drosophila DmXR, the residues of mGluRs involved in the binding of the alpha-carboxylic and alpha-amino groups of glutamate were well conserved in DdmGluPR, but the residues interacting with the gamma-carboxylic group of glutamate were not. The phylogenetic analysis suggests that DdmGluPR diverged after the mGluR family-GABA(B) receptors split but before mGluR family divergence. DdmGluPR mRNA was expressed in vegetative cells and throughout starvation-induced development, but the level of the expression was relatively high until 4 h after starvation. DdmGluPR was localized to the plasma membrane of axenically grown Ax-2 cells expressed as a green fluorescent protein fusion protein. DdmG...Continue Reading

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Citations

Oct 14, 2009·Journal of Molecular Neuroscience : MN·Samuel J Fountain
May 16, 2007·BMC Developmental Biology·Yogikala PrabhuAngelika A Noegel
Jul 19, 2012·Evolutionary Bioinformatics Online·Balasubramanian NagarathnamRamanathan Sowdhamini
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Jan 14, 2011·Pharmacological Reviews·Marcela Julio-PieperJohn F Cryan
Feb 15, 2018·Journal of Cell Science·Thomas D Williams, Robert R Kay

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