A metadata approach for clinical data management in translational genomics studies in breast cancer.

BMC Medical Genomics
Irene PapatheodorouCarlos Caldas

Abstract

In molecular profiling studies of cancer patients, experimental and clinical data are combined in order to understand the clinical heterogeneity of the disease: clinical information for each subject needs to be linked to tumour samples, macromolecules extracted, and experimental results. This may involve the integration of clinical data sets from several different sources: these data sets may employ different data definitions and some may be incomplete. In this work we employ semantic web techniques developed within the CancerGrid project, in particular the use of metadata elements and logic-based inference to annotate heterogeneous clinical information, integrate and query it. We show how this integration can be achieved automatically, following the declaration of appropriate metadata elements for each clinical data set; we demonstrate the practicality of this approach through application to experimental results and clinical data from five hospitals in the UK and Canada, undertaken as part of the METABRIC project (Molecular Taxonomy of Breast Cancer International Consortium). We describe a metadata approach for managing similarities and differences in clinical datasets in a standardized way that uses Common Data Elements (CDEs...Continue Reading

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Citations

Jul 17, 2013·Journal of Radiation Research·Faustin Laurentiu RomanJose Salt
Oct 23, 2015·British Journal of Cancer·Aisyah Mohd NoorAnita Grigoriadis
Feb 10, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Wilbert ZwartJason S Carroll
Dec 19, 2012·Journal of Biomedical Informatics·Sylvie M N NgouongoJürgen Stausberg
Jan 15, 2015·PloS One·Sebastian MateThomas Ganslandt
Jun 27, 2015·PloS One·Shiau-Mei ChenChen-Yang Shen
Jun 9, 2020·Journal of Family Medicine and Primary Care·Esmat MirbagheriSoraya Salmanian
Dec 16, 2020·BMC Medical Informatics and Decision Making·Hansi ZhangJiang Bian
May 26, 2021·Biopreservation and Biobanking·Pei-Fen ZhangWei-Hua Jia

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Software Mentioned

Jena Semantic Web Framework
SAWSDL
METABRIC
XPath
eXist
SPARQL
GraphViz
excel
CancerGrid
SQIV

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