Jan 1, 1976

A metal complexing property of furosemide and bumetanide: determination of pK and stability constant

Arzneimittel-Forschung
Y OritaH Abe

Abstract

Furosemide and bumetanide have been found to have different pK values and undergo complex formation with several metal ions in dioxane-water solution. pK values of these diuretics were determined. Evidence for complex formation was provided by a drop in pH during complex formation, production of a characteristic color and precipitation.

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Mentioned in this Paper

Salix - substance
Copper
Zinc
Diuretic Effect
Physicochemical Phenomena
Drug Stability
Metal Antagonists
Hydrogen-Ion Concentration
Miccil
Magnesium

About this Paper

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