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A method for calculating probabilities of fitness consequences for point mutations across the human genome

Nature Genetics

Jan 20, 2015

Brad GulkoAdam Siepel

Abstract

We describe a new computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These 'fitness consequence' (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genom...read more

Mentioned in this Paper

Genome
Pan troglodytes
Genomics
Human Umbilical Vein Endothelial Cells
Nucleotides
Genetic Fitness
Cell Type
Biochemical Turnover
Pan Genus
Probability
88
16
2
400
1
Paper Details
References
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  • Citations46
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  • References53
  • Citations46
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A method for calculating probabilities of fitness consequences for point mutations across the human genome

Nature Genetics

Jan 20, 2015

Brad GulkoAdam Siepel

PMID: 25599402

DOI: 10.1038/ng.3196

Abstract

We describe a new computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These 'fitness consequence' (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genom...read more

Mentioned in this Paper

Genome
Pan troglodytes
Genomics
Human Umbilical Vein Endothelial Cells
Nucleotides
Genetic Fitness
Cell Type
Biochemical Turnover
Pan Genus
Probability
88
16
2
400
1

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

PLoS Genetics

Hypermutable non-synonymous sites are under stronger negative selection

PLoS GeneticsDecember 2, 2008
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European Journal of Human Genetics : EJHG

Human genome: which proteins contribute to human-chimpanzee differences?

European Journal of Human Genetics : EJHGMarch 9, 2006
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Paper Details
References
  • References53
  • Citations46
12345...
  • References53
  • Citations46
12345
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