Get paper from

journal cover

A method for calculating probabilities of fitness consequences for point mutations across the human genome

Nature Genetics

Mar 1, 2015

Brad GulkoAdam C Siepel

Get paper from

Abstract

We describe a new computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These 'fitness consequence' (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genom...read more

88
16
2
376
1
Paper Details
References
    • References53
    • Citations33
    • References53
    • Citations33
  • A method for calculating probabilities of fitness consequences for point mutations across the human genome

    Nature Genetics

    Mar 1, 2015

    Brad GulkoAdam C Siepel

    PMID: 25599402

    DOI: 10.1038/ng.3196

    Abstract

    We describe a new computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These 'fitness consequence' (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genom...read more

    88
    16
    2
    376
    1
    Paper Details
    References
    • References53
    • Citations33
    • References53
    • Citations33
  • Get paper from

    Hi! We use cookies on this site for analytics purposes. Visit our cookie policy to learn more. By continuing to use our services or closing this banner, you consent to our use of cookies.

    /papers/a-method-for-calculating-probabilities-of-fitness/25599402