PMID: 3764222Jul 1, 1986Paper

A method for combining results from several prospective epidemiologic studies

Statistics in Medicine
A R Dyer

Abstract

An approach to the problem of a single study lacking adequate power to examine an important question is to combine the data from several studies to allow a more powerful test of the hypothesis in question. The present paper describes a method used by the International Collaborative Group to pool data on 54,492 men aged 40-69 from 10 population studies in 7 countries to examine the association between cholesterol level and risk of death from cancer. Furthermore, there was a suggestion that the inverse association observed in some studies might be the result of an effect of undetected cancer on cholesterol level, rather than an increase in cancer risk resulting from low cholesterol levels. This paper describes the process for selection of the method used to evaluate this possibility over other potential approaches and the results obtained in the analysis of the International Collaborative Group data that support this hypothesis. This report also indicates how one might expect some of the analyses described to compare with analyses based on a discrete version of the Cox proportional hazards model.

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Citations

Apr 24, 2007·Social Psychiatry and Psychiatric Epidemiology·Maria Victoria ZunzuneguiUNKNOWN CLESA Working Group
May 18, 2010·American Journal of Epidemiology·Soham Al SnihKenneth J Ottenbacher
Aug 4, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Beatriz Eugenia AlvaradoLourdes Tellechea
Mar 25, 1989·BMJ : British Medical Journal·W Y CraigJ E Haddow
Jun 25, 2009·Cancer Research·Isabelle Ray-CoquardUNKNOWN European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Dec 11, 2013·Journal of Occupational Rehabilitation·Cécile R L BootAllard J van der Beek
Feb 8, 2014·International Archives of Occupational and Environmental Health·Cécile R L BootAllard J van der Beek
Oct 1, 1991·British Journal of Addiction·B M JohnstoneE Hartka
Jul 1, 1987·The Journal of Diabetic Complications·E A Friedman
Jan 1, 2008·Journal of Aging and Health·Beatriz Eugenia AlvaradoMaria Victoria Zunzunegui
Dec 4, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Alessandro MenottiHisashi Adachi
Jan 30, 1995·Statistics in Medicine·D R Jones
Jun 30, 2011·European Journal of Epidemiology·Paolo Emilio PudduAnthony George Kafatos

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