A method for converting dose-to-medium to dose-to-tissue in Monte Carlo studies of gold nanoparticle-enhanced radiotherapy

Physics in Medicine and Biology
B Koger, Charles Kirkby

Abstract

Gold nanoparticles (GNPs) have shown potential in recent years as a means of therapeutic dose enhancement in radiation therapy. However, a major challenge in moving towards clinical implementation is the exact characterisation of the dose enhancement they provide. Monte Carlo studies attempt to explore this property, but they often face computational limitations when examining macroscopic scenarios. In this study, a method of converting dose from macroscopic simulations, where the medium is defined as a mixture containing both gold and tissue components, to a mean dose-to-tissue on a microscopic scale was established. Monte Carlo simulations were run for both explicitly-modeled GNPs in tissue and a homogeneous mixture of tissue and gold. A dose ratio was obtained for the conversion of dose scored in a mixture medium to dose-to-tissue in each case. Dose ratios varied from 0.69 to 1.04 for photon sources and 0.97 to 1.03 for electron sources. The dose ratio is highly dependent on the source energy as well as GNP diameter and concentration, though this effect is less pronounced for electron sources. By appropriately weighting the monoenergetic dose ratios obtained, the dose ratio for any arbitrary spectrum can be determined. This ...Continue Reading

References

Apr 5, 2002·Medical Physics·Daryoush Sheikh-Bagheri, D W O Rogers
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Jul 21, 2005·Physics in Medicine and Biology·Frank VerhaegenDimitre Hristov
Jan 1, 2008·Small·Nastassja LewinskiRebekah Drezek
Sep 3, 2009·Physics in Medicine and Biology·G PoludniowskiF Verhaegen
May 14, 2010·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Sep 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephen J McMahonFred J Currell
Sep 21, 2011·Medical Physics·Rowan M Thomson, Iwan Kawrakow
Feb 23, 2012·Scientific Reports·Stephen J McMahonFred J Currell
Nov 3, 2012·Radiation Protection Dosimetry·H M Garnica-Garza
Nov 15, 2012·Radiation Research·Ross I BerbecoG Mike Makrigiorgos
Dec 26, 2012·Nanomedicine·James F HainfeldDaniel N Slatkin
Feb 8, 2013·Medical Physics·Piotr ZygmanskiErno Sajo
Oct 31, 2013·Physics in Medicine and Biology·Piotr ZygmanskiErno Sajo
Oct 3, 2015·Medical Physics·Joseph T RakowskiGavin Lawes

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Citations

Dec 22, 2016·Medical Physics·Martin P Martinov, Rowan M Thomson
Jun 7, 2018·Physics in Medicine and Biology·Wonmo Sung, Jan Schuemann
May 5, 2018·Advanced Healthcare Materials·Myriam Laprise-PelletierMarc-André Fortin
Oct 11, 2017·Medical Physics·Charles KirkbyDavid R McKenzie
Mar 13, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Sherif M GadoueErno Sajo
Mar 27, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·H RabusH Nettelbeck

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