PMID: 7939389Jan 1, 1994Paper

A method for distinguishing ionized, complexed and protein-bound Mg in normal and diseased subjects

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
B T Altura, B M Altura

Abstract

Since 1932, it has been known that Mg exists in blood in several forms: protein-bound, complexed to certain anions, and ionized. However, there is discrepancy and debate on what these fractions are, how to accurately assess them, and whether they are important in diagnosis and prognosis of disease syndromes. Using the NOVA ISE for IMg2+, a controlled method for ultrafiltration of Mg and atomic absorption spectrophotometry, we have found four distinct fractions of Mg in healthy normal plasma and serum: 1. ultrafilterable Mg (81%) (made up of ionized and complexed); 2. ionized Mg (67%); 3. protein-bound Mg (19%); and 4. complexed Mg (14%). The amount of each fraction appears to depend upon the pathophysiologic state of the patients. Previous observations on the amount of complexed and ionized Mg are at best, only approximations, due to the absence of a device (i.e., ISE) to measure accurately IMg2+.

References

Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B T AlturaB M Altura
Sep 1, 1939·The Journal of Clinical Investigation·L J SofferM D Jacobs
Jul 1, 1941·The Journal of Clinical Investigation·L J SofferH Sobotka
Feb 1, 1949·Canadian Journal of Research. Section E, Medical Sciences·J B R COSGROVE, W F PERRY

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Citations

Aug 26, 2000·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·I J Newhouse, E W Finstad
Mar 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·W R KülpmannA Schüler
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Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B T AlturaB M Altura
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Aug 3, 2006·American Journal of Veterinary Research·Ignacio LopezEscolastico Aguilera-Tejero
Jan 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B M Altura, B T Altura
Jan 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·N Fogh-AndersenO Siggaard-Andersen
Mar 17, 2001·Medicine and Science in Sports and Exercise·E W FinstadC R Stewart

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