PMID: 8971990Nov 1, 1996Paper

A method for estimating respiratory muscle efficiency using an automated metabolic cart

Respiration Physiology
M S ShermanD Campbell

Abstract

We measured respiratory muscle efficiency (RME) in twelve healthy human subjects by dividing the added energy cost of breathing against a threshold resistance load by the associated increase in caloric expenditure. Caloric expenditure was calculated using steady-state measurements of oxygen consumption and carbon dioxide production during loaded and unloaded breathing. Calculated RME ranged from 1.7% to 5.5% (mean 3.5%). The coefficient of variation in six subjects averaged 13%. We compared these calculations with a previously described oxygen consumption-based method that did not incorporate carbon dioxide production measurements. We found that changes in the respiratory quotient during resistive breathing could cause significant errors in oxygen consumption-based calculations of RME. Limits of agreement of 95% suggest that the oxygen-consumption-based calculations could potentially overestimate efficiency by as much as 5.0% or underestimate by up to 3.4%. We recommend that carbon dioxide production be measured when this technique for estimation of RME is used. This can be easily accomplished through the use of an automated metabolic cart.

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Citations

Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Michael S ShermanTerry Heiman-Patterson

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