Mar 8, 2020

A Method for Large Scale Implantation of 3D Microdevice Ensembles into Brain and Soft Tissue

bioRxiv
Stefan A SigurdssonArto Nurmikko

Abstract

Wireless networks of implantable electronic sensors and actuators on the microscale (sub-mm) are being explored for monitoring and modulation of physiological activity for medical diagnostics and therapeutic purposes. Beyond the requirement of integrating multiple electronic or chemical functions within small device volumes, a key challenge is the development of high-throughput methods for implantation of large numbers of microdevices into soft tissues with minimal damage. To that end, we have developed a method for high-throughput implantation of ~100-200 μm size devices which are here simulated by proxy microparticle ensembles. While generally applicable, our main focus and experimental testbed is the implantation of microparticles into the brain. The method deploys a scalable delivery tool composed of a 2-dimensional array of Polyethylene Glycol (PEG) tipped microneedles which confine the microparticle payloads. Upon dissolution of the bioresorbable PEG, the supporting array structure is retrieved and the microparticles remain embedded in the tissue, distributed spatially and geometrically according to the design of the microfabricated delivery tool. We evaluate the method in an agarose testbed in terms of spatial precision ...Continue Reading

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Mentioned in this Paper

Cerebral Cortex
Implantation Procedure
Soft Tissue
Array
Particle
Needle Device
Spherical Shape
Implants
Polyethylene Glycols
Rodent

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