A Method for Manufacturing Oncological Phantoms for the Quantification of 18F-FDG PET and DW-MRI Studies

Contrast Media & Molecular Imaging
Francesca GallivanoneIsabella Castiglioni

Abstract

The aim of this work was to develop a method to manufacture oncological phantoms for quantitation purposes in 18F-FDG PET and DW-MRI studies. Radioactive and diffusion materials were prepared using a mixture of agarose and sucrose radioactive gels. T2 relaxation and diffusion properties of gels at different sucrose concentrations were evaluated. Realistic oncological lesions were created using 3D-printed plastic molds filled with the gel mixture. Once solidified, gels were extracted from molds and immersed in a low-radioactivity gel simulating normal background tissue. A breast cancer phantom was manufactured using the proposed method as an exploratory feasibility study, including several realistic oncological configurations in terms of both radioactivity and diffusion. The phantom was acquired in PET with 18F-FDG, immediately after solidification, and in DW-MRI the following day. Functional volumes characterizing the simulated BC lesions were segmented from PET and DW-MRI images. Measured radioactive uptake and ADC values were compared with gold standards. Phantom preparation was straightforward, and the time schedule was compatible with both PET and MRI measurements. Lesions appeared on 18F-FDG PET and DW-MRI images as expect...Continue Reading

References

Dec 16, 1998·Journal of Magnetic Resonance Imaging : JMRI·H J LaubachS Warach
Mar 4, 2005·Physics in Medicine and Biology·Irène BuvatMaria-Carla Gilardi
May 22, 2010·AJR. American Journal of Roentgenology·Savannah C PartridgeConstance D Lehman
Apr 12, 2013·Journal of Magnetic Resonance Imaging : JMRI·Ioannis LavdasEric O Aboagye
Oct 15, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sergios GatidisNina F Schwenzer
Oct 29, 2013·BioMed Research International·F GallivanoneI Castiglioni

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Citations

Jul 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Isabella CastiglioniMarco Salvatore
Aug 27, 2021·EJNMMI Physics·Eve LennieSteven Sourbron

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Matlab

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