PMID: 11926381Apr 3, 2002Paper

A method for measurement of the uptake patterns of two beta-emitting radionuclides in the same tissue section with a digital silicon detector: application to a study of 89SrCl2 and 153Sm-EDTMP in a dog with spontaneous osteosarcoma

European Journal of Nuclear Medicine and Molecular Imaging
Y KvinnslandA Skretting

Abstract

The biological effect of a radiopharmaceutical depends heavily on the heterogeneity of the uptake in the various tissues. A comparative study of two radiopharmaceuticals should therefore include a comparison of the uptake patterns in different tissues. To eliminate the problems caused by variation in kinetics and tumour characteristics between individuals, such a comparison should be based on measured distributions of the radiopharmaceuticals in the same tissue sample. The excellent linearity between activity and counts in images obtained with a digital silicon strip detector allows such distributions to be derived from two autoradiographs acquired at different time points. This method was applied in a comparison of the uptake patterns of 153Sm-EDTMP and 89SrCl2 in sections obtained from a dog with spontaneous osteosarcoma, containing both tumour and normal bone tissues. As the areas of the section were larger than the detector area, the section had to be cut into smaller parts. Images of these were later merged by means of image processing techniques. There were significant differences in the uptake patterns of the two nuclides. In the primary tumour, the uptake of 153Sm was highly heterogeneous, while 89Sr was more uniformly ...Continue Reading

Citations

Oct 23, 2009·Physics in Medicine and Biology·Jennifer S ChoArion F Chatziioannou
Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·P Lass, J Scheffler
Mar 29, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Sudipta ChakrabortySharmila Banerjee
Jul 25, 2006·Expert Opinion on Pharmacotherapy·Pete Anderson
Jun 27, 2003·Applied Microbiology and Biotechnology·K PlháckováP Kyslík

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