A method for measuring the size distribution of latex particles by scanning force microscopy

Ultramicroscopy
G RoeA Ghanem

Abstract

A methodology has been developed to accurately determine the size distribution of latex particles using the scanning force microscope (SFM). Unlike other workers, who have generally measured the lateral dimensions of monolayers of latex particles using a global quantification method, we have measured the heights of individual latex particles located at the edges of latex monolayers that were immobilised onto mica substrates. In agreement with other work, we noted that the edges of monolayers of latex particles provided stable and reproducible scanning force imaging. Whilst SFM imaging noise, image processing artifacts, tip/sample forces and variations in the mica substrate are sources of measurement error that should not be overlooked, our experience has been that the variation over time of the sensitivity of the Z actuator is the greatest potential uncertainty in determining the heights of latex particles. The methodology that we used requires frequent calibration of the Z actuator of the SFM, typically before and after two or three images, in order to ensure that the uncertainties in the Z sensitivity are known and minimised. This methodology was developed for an SFM instrument that was equipped with open loop piezoelectric a...Continue Reading

Citations

Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Michel RabanelXavier Banquy
Nov 14, 2013·Journal of the American Geriatrics Society·Belinda J ParmenterMaria A Fiatarone Singh

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