PMID: 8607Jul 1, 1976

A method for screening diuretic agents in the mouse: an investigation of sexual differences

The Journal of Pharmacy and Pharmacology
T W Hill, P J Randall

Abstract

Acetazolamide, aminophyline, frusemide, ethacrynic acid and triamterene were tested for diuretic action at dosages of 3, 10 and 30 mg kg-1 (s.c.) in male and female mice. Each drug significantly raised sodium excretion and all but acetazolamide elevated urine volume and chloride excretion. Potassium excretion was significantly raised by acetazolamide and frusemide. Acetazolamide and triamterene evoked urinary alkalinization whereas frusemide and ethacrynic acid reduced urinary pH. Female mice were markedly more sensitive than males to the diuretic, natriuretic, chloruretic and urinary acidfying actions of ethacrynic acid.

References

Sep 1, 1969·Comparative Biochemistry and Physiology·J Stewart
Sep 1, 1968·The Journal of Physiology·J Stewart

Citations

Aug 1, 1977·British Journal of Pharmacology·M J Cooling, M F Sim
Jun 28, 2019·Drug Development Research·Angel Josabad Alonso-CastroMarco Antonio Ramírez-Morales

Related Concepts

Chloride Ion Level
Diuretic Effect
Medicinal Plants Testing, Preclinical
Estrus
Hydrogen-Ion Concentration
Mice, Inbred Strains
Potassium
Sodium

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